MST1 dimer:MST1R dimer binds MST1R dimer

Stable Identifier
R-HSA-8852522
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
MST1R dimer dimerises
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MST1 dimer:MST1R dimer binds MST1R dimer
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The receptor tyrosine kinase macrophage stimulating 1 receptor (MST1R, aka recepteur d'origine nantais, RON) is the cell surface receptor for macrophage stimulating protein 1 (MST1, aka MSP). Once ligand binding takes place, MST1R can undergo homodimerisation (Miller & Leonard 1998, Chao et al. 2014).

Literature References
PubMed ID Title Journal Year
9657372 Mode of receptor binding and activation by plasminogen-related growth factors

Miller, M, Leonard, EJ

FEBS Lett. 1998
25193665 Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein

Chao, KL, Gorlatova, NV, Eisenstein, E, Herzberg, O

J. Biol. Chem. 2014
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Orthologous Events
MST1 dimer:MST1R dimer binds MST1R dimer (Bos taurus)
MST1 dimer:MST1R dimer binds MST1R dimer (Canis familiaris)
MST1 dimer:MST1R dimer binds MST1R dimer (Danio rerio)
MST1 dimer:MST1R dimer binds MST1R dimer (Gallus gallus)
MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)
MST1 dimer:MST1R dimer binds MST1R dimer (Rattus norvegicus)
MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)
Authored
Jassal, B  (2016-01-19)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2016-01-19)
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