MST1 dimer:MST1R dimer binds MST1R dimer

Stable Identifier
R-HSA-8852522
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
MST1R dimer dimerises
ReviewStatus
5/5
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MST1 dimer:MST1R dimer binds MST1R dimer
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The receptor tyrosine kinase macrophage stimulating 1 receptor (MST1R, aka recepteur d'origine nantais, RON) is the cell surface receptor for macrophage stimulating protein 1 (MST1, aka MSP). Once ligand binding takes place, MST1R can undergo homodimerisation (Miller & Leonard 1998, Chao et al. 2014).

Literature References
PubMed ID Title Journal Year
25193665 Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein

Gorlatova, NV, Herzberg, O, Chao, KL, Eisenstein, E

J. Biol. Chem. 2014
9657372 Mode of receptor binding and activation by plasminogen-related growth factors

Miller, M, Leonard, EJ

FEBS Lett. 1998
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Orthologous Events
MST1 dimer:MST1R dimer binds MST1R dimer (Bos taurus)
MST1 dimer:MST1R dimer binds MST1R dimer (Caenorhabditis elegans)
MST1 dimer:MST1R dimer binds MST1R dimer (Canis familiaris)
MST1 dimer:MST1R dimer binds MST1R dimer (Danio rerio)
MST1 dimer:MST1R dimer binds MST1R dimer (Gallus gallus)
MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)
MST1 dimer:MST1R dimer binds MST1R dimer (Rattus norvegicus)
MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)
MST1 dimer:MST1R dimer binds MST1R dimer (Xenopus tropicalis)
Authored
Jassal, B  (2016-01-19)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2016-01-19)
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