Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates

Stable Identifier
R-HSA-8852481
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Binding of the plasma protease C1 inhibitor (C1Inh, SERPING1) to the C1s and C1r subunits of the C1 complex leads to C1 disassembly, releasing inactive C1r:C1Inh and C1s:C1Inh complexes (Arlaud et al. 1979, Sim et al. 1979, Ziccardi & Cooper 1979). Thus C1Inh plays an important role in regulating nonspecific complement activation (Ziccardi et al. 1983).

Literature References
PubMed ID Title Journal Year
760802 Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1

Arlaud, GJ, Reboul, A, Sim, RB, Colomb, MG

Biochim. Biophys. Acta 1979
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created