Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates

Stable Identifier
R-HSA-8852481
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates
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Binding of the plasma protease C1 inhibitor (C1Inh, SERPING1) to the C1s and C1r subunits of the C1 complex leads to C1 disassembly, releasing inactive C1r:C1Inh and C1s:C1Inh complexes (Arlaud et al. 1979, Sim et al. 1979, Ziccardi & Cooper 1979). Thus C1Inh plays an important role in regulating nonspecific complement activation (Ziccardi et al. 1983).
Literature References
PubMed ID Title Journal Year
760802 Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1

Sim, RB, Arlaud, GJ, Reboul, A, Colomb, MG

Biochim. Biophys. Acta 1979
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Orthologous Events
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Bos taurus)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Canis familiaris)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Gallus gallus)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Rattus norvegicus)
Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Sus scrofa)
Authored
Jupe, S  (2016-01-06)
Reviewed
Bulla, R  (2017-02-01)
Created
Jupe, S  (2016-01-18)
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