GTSE1 facilitates proteasome-mediated degradation of TP53

Stable Identifier
Reaction [omitted]
Homo sapiens
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GTSE1 promotes down-regulation of TP53 in a proteasome-dependent way. Nuclear export of TP53 facilitated by GTSE1 and MDM2likely makes ubiquitinated TP53 available to the proteasome machinery. GTSE1-mediated decrease of TP53 levels is needed for the G2 checkpoint recovery (cell cycle re-entry after DNA damage induced G2 arrest) and rescues cells from DNA damage induced apoptosis during S/G2 phase (Monte et al. 2003, Monte et al. 2004).

Literature References
PubMed ID Title Journal Year
12750368 The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function

Del Sal, G, Schneider, C, Buscemi, G, Sandy, P, Monte, M, Benetti, R

J. Biol. Chem. 2003
14707141 hGTSE-1 expression stimulates cytoplasmic localization of p53

Del Sal, G, Collavin, L, Schneider, C, Monte, M, Marchionni, L, Benetti, R

J. Biol. Chem. 2004
Event Information
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
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