GTSE1 facilitates proteasome-mediated degradation of TP53

Stable Identifier
R-HSA-8852354
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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GTSE1 facilitates proteasome-mediated degradation of TP53
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GTSE1 promotes down-regulation of TP53 in a proteasome-dependent way. Nuclear export of TP53 facilitated by GTSE1 and MDM2likely makes ubiquitinated TP53 available to the proteasome machinery. GTSE1-mediated decrease of TP53 levels is needed for the G2 checkpoint recovery (cell cycle re-entry after DNA damage induced G2 arrest) and rescues cells from DNA damage induced apoptosis during S/G2 phase (Monte et al. 2003, Monte et al. 2004).
Literature References
PubMed ID Title Journal Year
12750368 The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function

Monte, M, Benetti, R, Buscemi, G, Sandy, P, Del Sal, G, Schneider, C

J. Biol. Chem. 2003
14707141 hGTSE-1 expression stimulates cytoplasmic localization of p53

Monte, M, Benetti, R, Collavin, L, Marchionni, L, Del Sal, G, Schneider, C

J. Biol. Chem. 2004
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Event Information
Go Biological Process
proteasome-mediated ubiquitin-dependent protein catabolic process (0043161)
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Mus musculus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Rattus norvegicus)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-15)
Reviewed
Bird, AW  (2016-01-22)
Created
Orlic-Milacic, M  (2016-01-16)
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