Since MDM2-mediated ubiquitination of TP53 promotes translocation of TP53 to the cytosol, and since GTSE1-facilitated translocation of TP53 to the cytosol depends on the functional MDM2 (with no reported interaction between GTSE1 and MDM2) (Monte et al. 2004), it is plausible that GTSE1 binds to TP53 polyubiquitinated by MDM2. The interaction between TP53 and GTSE1 involves the C-terminal regulatory domain of TP53 and the C-terminus of GTSE1 (Monte et al. 2003).
Del Sal, G, Schneider, C, Buscemi, G, Sandy, P, Monte, M, Benetti, R
Del Sal, G, Collavin, L, Schneider, C, Monte, M, Marchionni, L, Benetti, R
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