GTSE1 binds TP53

Stable Identifier
R-HSA-8852337
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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GTSE1 binds TP53
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Since MDM2-mediated ubiquitination of TP53 promotes translocation of TP53 to the cytosol, and since GTSE1-facilitated translocation of TP53 to the cytosol depends on the functional MDM2 (with no reported interaction between GTSE1 and MDM2) (Monte et al. 2004), it is plausible that GTSE1 binds to TP53 polyubiquitinated by MDM2. The interaction between TP53 and GTSE1 involves the C-terminal regulatory domain of TP53 and the C-terminus of GTSE1 (Monte et al. 2003).
Literature References
PubMed ID Title Journal Year
12750368 The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function

Monte, M, Benetti, R, Buscemi, G, Sandy, P, Del Sal, G, Schneider, C

J. Biol. Chem. 2003
14707141 hGTSE-1 expression stimulates cytoplasmic localization of p53

Monte, M, Benetti, R, Collavin, L, Marchionni, L, Del Sal, G, Schneider, C

J. Biol. Chem. 2004
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Orthologous Events
GTSE1 binds TP53 (Bos taurus)
GTSE1 binds TP53 (Canis familiaris)
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GTSE1 binds TP53 (Rattus norvegicus)
GTSE1 binds TP53 (Sus scrofa)
GTSE1 binds TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-15)
Reviewed
Bird, AW  (2016-01-22)
Created
Orlic-Milacic, M  (2016-01-16)
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