PLK1 phosphorylates GTSE1

Stable Identifier
R-HSA-8852317
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PLK1 phosphorylates GTSE1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated PLK1 phosphorylates GTSE1 on serine residue S435, located in immediate vicinity of the GTSE1 nuclear localization signal (NLS) R431RR433 (Arg431Arg432Arg433). PLK1-mediated phosphorylation promotes GTSE1 nuclear translocation, possibly by exposing the NLS of GTSE1 to the nuclear import machinery. PLK1 can also phosphorylate human GTSE1 on serine residue S233. S233 is not evolutionarily conserved and is therefore not shown (Liu et al. 2010).
Literature References
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of protein localization to nucleus (1900182)
Catalyst Activity

protein serine/threonine kinase activity of GTSE1:p-T210-PLK1 [cytosol]

Physical Entity
GTSE1:p-T210-PLK1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PLK1 phosphorylates GTSE1 (Bos taurus)
PLK1 phosphorylates GTSE1 (Canis familiaris)
PLK1 phosphorylates GTSE1 (Danio rerio)
PLK1 phosphorylates GTSE1 (Gallus gallus)
PLK1 phosphorylates GTSE1 (Mus musculus)
PLK1 phosphorylates GTSE1 (Rattus norvegicus)
PLK1 phosphorylates GTSE1 (Sus scrofa)
PLK1 phosphorylates GTSE1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-15)
Reviewed
Bird, AW  (2016-01-22)
Created
Orlic-Milacic, M  (2016-01-15)
Cite Us!