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C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s
Stable Identifier
R-HSA-8852266
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)
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The plasma protease C1 inhibitor (C1Inh, SERPING1) can bind the activated C1r and C1s proteases in the activated C1 complex, rendering them proteolytically inactive (Sim et al. 1979a) and leading to the disassembly of the C1 complex, releasing inactive C1r:C1Inh and C1s:C1Inh complexes (Arlaud et al. 1979, Sim et al. 1979b, Ziccardi & Cooper 1979). C1Inh also inhibits and controls certain non-antibody-induced as well as spontaneous C1 activation. Thus C1Inh plays an important role in regulating nonspecific complement activation (Ziccardi et al. 1983). C1Inh is also a major physiological inhibitor of kallikrein (Ratnoff et al. 1969), coagulation factors XIa and XIIa (Forbes et al. 1970), and the enzymatically active fragments derived from factor XIIa (factor XIIf) (Schreiber et al. 1973).
Literature References
PubMed ID
Title
Journal
Year
761607
Interaction of 125I-labelled complement subcomponents C-1r and C-1s with protease inhibitors in plasma
Sim, RB
,
Arlaud, GJ
,
Reboul, A
,
Villiers, CL
,
Colomb, MG
FEBS Lett.
1979
Participants
Input
Antigen:IgG:C1Q:2x Activated C1R:2x Activated C1S [plasma membrane]
(Homo sapiens)
x 4
SERPING1 [extracellular region]
(Homo sapiens)
Output
Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane]
(Homo sapiens)
Participates
as an event of
Regulation of Complement cascade (Homo sapiens)
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C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Gallus gallus)
C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)
C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Rattus norvegicus)
C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Sus scrofa)
Authored
Jupe, S (2016-01-06)
Reviewed
Bulla, R (2017-02-01)
Created
Jupe, S (2016-01-15)
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