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UBE2A [nucleoplasm]
Stable Identifier
R-HSA-8852048
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin-conjugating enzyme E2 A ecNumber evidence="5"2.3.2.23/ecNumber, UBE2A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
UBE2A,B [nucleoplasm] (Homo sapiens)
UBE2A [nucleoplasm] (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
UBE2A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49459 UBE2A
Gene Names
UBE2A, RAD6A
Chain
chain:1-152
Reference Genes
BioGPS Gene:7319 UBE2A
COSMIC (genes):UBE2A UBE2A
CTD Gene:7319 UBE2A
dbSNP Gene:7319 UBE2A
ENSEMBL:ENSG00000077721 UBE2A
ENSEMBL:ENSG00000077721.17 UBE2A
HGNC:12472 UBE2A
KEGG Gene (Homo sapiens):7319 UBE2A
Monarch:7319 UBE2A
NCBI Gene:7319 UBE2A
OMIM:312180 UBE2A
UCSC:P49459 UBE2A
Reference Transcript
RefSeq:NM_001282161.1 UBE2A
RefSeq:NM_181762.2 UBE2A
RefSeq:NM_003336.3 UBE2A
Other Identifiers
11716265_a_at
11716266_s_at
11740193_s_at
17106587
201898_PM_s_at
201898_s_at
201899_PM_s_at
201899_s_at
3988875
3988876
3988877
3988878
3988887
3988890
3988893
3988894
3988895
7319
8169645
890_at
A_14_P135088
A_23_P148446
A_33_P3341189
GE58069
GO:0000086
GO:0000166
GO:0000209
GO:0000278
GO:0000785
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006281
GO:0006301
GO:0006325
GO:0006338
GO:0006511
GO:0006974
GO:0009411
GO:0016567
GO:0016574
GO:0016740
GO:0019787
GO:0030163
GO:0031625
GO:0033503
GO:0033522
GO:0036211
GO:0043130
GO:0043161
GO:0043226
GO:0051865
GO:0061631
GO:0070936
GO:0070979
GO:0140096
GO:0140852
HMNXSV003042605
Hs.80612.0.S1_3p_a_at
ILMN_2307455
M74524_at
PH_hs_0018434
TC0X000587.hg
g4507768_3p_a_at
Participates
as a member of
E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
UBE2A,B [nucleoplasm] (Homo sapiens)
Other forms of this molecule
UBE2A [cytosol]
Ub-C88-UBE2A [nucleoplasm]
Inferred To
ubc2 [nucleoplasm]
(Dictyostelium discoideum)
mp:zf637-2-000771 [nucleoplasm]
(Danio rerio)
ube2a [nucleoplasm]
(Xenopus tropicalis)
UBE2A [nucleoplasm]
(Bos taurus)
UBE2A [nucleoplasm]
(Canis familiaris)
UBE2A [nucleoplasm]
(Gallus gallus)
UBE2A [nucleoplasm]
(Plasmodium falciparum)
UBE2A [nucleoplasm]
(Sus scrofa)
ubc-1 [nucleoplasm]
(Caenorhabditis elegans)
Ubc6 [nucleoplasm]
(Drosophila melanogaster)
Ube2a [nucleoplasm]
(Mus musculus)
Ube2a [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_003327.2
,
NP_001269090.1
,
NP_861427.1
OpenTargets
ENSG00000077721
IntEnz
2.3.2.23
GeneCards
P49459
HPA
ENSG00000077721-UBE2A
Ensembl
ENST00000625938
,
ENSP00000360613
,
ENSG00000077721
,
ENSP00000486550
,
ENSP00000486599
,
ENST00000630695
,
ENST00000371558
,
ENSP00000512695
,
ENST00000696534
PRO
P49459
Pharos - Targets
P49459
Orphanet
17261
HMDB Protein
HMDBP00560
PDB
6CYR
,
6CYO
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.718
9
UniProt:P55212 CASP6
5
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:Q8WZA2 RAPGEF4
1
RAPGEF4 [plasma membrane]
(R-HSA-3008666)
0.556
3
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P54652 HSPA2
2
HSPA2 [cytosol]
(R-HSA-3371408)
HSPA2 [nucleoplasm]
(R-HSA-912480)
0.556
3
UniProt:Q14957 GRIN2C
3
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
GRIN2C [plasma membrane]
(R-HSA-419560)
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
0.556
3
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