Activated MET binds GAB1 and GRB2

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

While GAB1 can bind activated MET receptor directly, the presence of GRB2 results in a more stable association between GAB1 and MET (Weidner et al. 1996, Schaeper et al. 2000, Lock et al. 2003).

Literature References
PubMed ID Title Journal Year
8906793 Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

Weidner, KM, Di Cesare, S, Sachs, M, Brinkmann, V, Behrens, J, Birchmeier, W

Nature 1996
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
12766170 Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain

Lock, LS, Frigault, MM, Saucier, C, Park, M

J Biol Chem 2003
Participant Of
Orthologous Events
Cite Us!