Reactome | RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET

RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET

Stable Identifier

R-HSA-8851899

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET

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SOS1, recruited to activated MET receptor via interaction of GRB2 with phosphorylated SHC1-2, catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Pelicci et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7731718	The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein Pelicci, G, Giordano, S, Zhen, Z, Salcini, AE, Lanfrancone, L, Bardelli, A, Panayotou, G, Waterfield, MD, Ponzetto, C, Pelicci, PG	Oncogene	1995