MET phosphorylates SHC1-2

Stable Identifier
R-HSA-8851890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated MET receptor phosphorylates the splicing isoform 2 of the adapter protein SHC1 (SHC1-2) on tyrosine residue Y317 (Pelicci et al. 1995).

Literature References
PubMed ID Title Journal Year
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Bardelli, A, Zhen, Z, Waterfield, MD, Lanfrancone, L, Salcini, AE, Ponzetto, C, Giordano, S, Pelicci, G, Pelicci, PG, Panayotou, G

Oncogene 1995
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane]

Orthologous Events
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