MET binds SHC1-2

Stable Identifier
R-HSA-8851888
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MET binds SHC1-2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated tyrosine residues Y1349 and Y1356 in the cytoplasmic tail of MET create docking sites for the SH2 domain of SHC1 splicing isoform 2 (SHC1-2) (Pelicci et al. 1995).

Literature References
PubMed ID Title Journal Year
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Bardelli, A, Zhen, Z, Waterfield, MD, Lanfrancone, L, Salcini, AE, Ponzetto, C, Giordano, S, Pelicci, G, Pelicci, PG, Panayotou, G

Oncogene 1995
Participants
Input
Output
Participates
as an event of
Orthologous Events
MET binds SHC1-2 (Danio rerio)
MET binds SHC1-2 (Gallus gallus)
MET binds SHC1-2 (Mus musculus)
MET binds SHC1-2 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Birchmeier, W  (2016-07-11)
Heynen, G  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-11)
Cite Us!