MET binds SHC1-2

Stable Identifier
R-HSA-8851888
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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MET binds SHC1-2
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Phosphorylated tyrosine residues Y1349 and Y1356 in the cytoplasmic tail of MET create docking sites for the SH2 domain of SHC1 splicing isoform 2 (SHC1-2) (Pelicci et al. 1995).

Literature References
PubMed ID Title Journal Year
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Pelicci, G, Giordano, S, Zhen, Z, Salcini, AE, Lanfrancone, L, Bardelli, A, Panayotou, G, Waterfield, MD, Ponzetto, C, Pelicci, PG

Oncogene 1995
Participants
Input
Output
Participant Of
hasEvent
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Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)