RAS guanyl nucleotide exchange factor SOS1 recruited to MET receptor through association with RANBP9 catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Wang et al. 2002).
Wang, D, Li, Z, Messing, EM, Wu, G
guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]
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