RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET

Stable Identifier
R-HSA-8851877
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
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RAS guanyl nucleotide exchange factor SOS1 recruited to MET receptor through association with RANBP9 catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Wang et al. 2002).

Literature References
PubMed ID Title Journal Year
12147692 Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM

Wang, D, Li, Z, Messing, EM, Wu, G

J. Biol. Chem. 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]
Physical Entity
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Caenorhabditis elegans)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Gallus gallus)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Rattus norvegicus)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Sus scrofa)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)