RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET

Stable Identifier
R-HSA-8851877
Type
Reaction
Species
Homo sapiens
Compartment
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RAS guanyl nucleotide exchange factor SOS1 recruited to MET receptor through association with RANBP9 catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Wang et al. 2002).

Literature References
PubMed ID Title Journal Year
12147692 Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM

Wang, D, Li, Z, Messing, EM, Wu, G

J. Biol. Chem. 2002
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]

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