Reactome | MET binds RANBP10

MET binds RANBP10

Stable Identifier

R-HSA-8851866

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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The sprouty (SPRY) domain of RANBP10 binds the tyrosine kinase domain of MET. RANBP10 binding inhibits binding of RANBP9 to MET and, as RANBP10 does not interact with SOS1, RANBP10 binding interferes with RAS activation (Wang et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14684163	A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling Wang, D, Schoen, SR, Li, Z, Messing, EM, Wu, G	Biochem. Biophys. Res. Commun.	2004