MET binds RANBP10

Stable Identifier
R-HSA-8851866
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The sprouty (SPRY) domain of RANBP10 binds the tyrosine kinase domain of MET. RANBP10 binding inhibits binding of RANBP9 to MET and, as RANBP10 does not interact with SOS1, RANBP10 binding interferes with RAS activation (Wang et al. 2004).

Literature References
PubMed ID Title Journal Year
14684163 A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling

Wang, D, Li, Z, Schoen, SR, Messing, EM, Wu, G

Biochem. Biophys. Res. Commun. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed