MET binds RANBP10

Stable Identifier
R-HSA-8851866
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Summation

The sprouty (SPRY) domain of RANBP10 binds the tyrosine kinase domain of MET. RANBP10 binding inhibits binding of RANBP9 to MET and, as RANBP10 does not interact with SOS1, RANBP10 binding interferes with RAS activation (Wang et al. 2004).

Literature References
PubMed ID Title Journal Year
14684163 A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling

Wang, D, Li, Z, Schoen, SR, Messing, EM, Wu, G

Biochem. Biophys. Res. Commun. 2004
Participants
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Participant Of
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Orthologous Events
MET binds RANBP10 (Bos taurus)
MET binds RANBP10 (Canis familiaris)
MET binds RANBP10 (Danio rerio)
MET binds RANBP10 (Gallus gallus)
MET binds RANBP10 (Mus musculus)
MET binds RANBP10 (Rattus norvegicus)
MET binds RANBP10 (Sus scrofa)
MET binds RANBP10 (Taeniopygia guttata)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)