MET binds RANBP10

Stable Identifier
R-HSA-8851866
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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MET binds RANBP10
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The sprouty (SPRY) domain of RANBP10 binds the tyrosine kinase domain of MET. RANBP10 binding inhibits binding of RANBP9 to MET and, as RANBP10 does not interact with SOS1, RANBP10 binding interferes with RAS activation (Wang et al. 2004).

Literature References
PubMed ID Title Journal Year
14684163 A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling

Wang, D, Li, Z, Schoen, SR, Messing, EM, Wu, G

Biochem. Biophys. Res. Commun. 2004
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Orthologous Events
MET binds RANBP10 (Danio rerio)
MET binds RANBP10 (Gallus gallus)
MET binds RANBP10 (Mus musculus)
MET binds RANBP10 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)
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