Reactome | Activated MET binds RANBP9 and SOS1

Activated MET binds RANBP9 and SOS1

Stable Identifier

R-HSA-8851859

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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RANBP9 binds to activated MET receptor and recruits RAS guanyl nucleotide exchange factor SOS1. RANBP9 can associate with unphosphorylated MET, but has a higher affinity for the activated receptor. The interaction involves the sprouty (SPRY) domain of RANBP9 and the tyrosine kinase domain of MET (Wang et al. 2002). RANBP9 competes with RANBP10 for MET binding. RANBP10 does not interact with SOS1, and RANBP10 binding inhibits activation of RAS downstream of MET (Wang et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14684163	A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling Wang, D, Schoen, SR, Li, Z, Messing, EM, Wu, G	Biochem. Biophys. Res. Commun.	2004
12147692	Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM Wang, D, Li, Z, Messing, EM, Wu, G	J. Biol. Chem.	2002