Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Activated MET binds RANBP9 and SOS1
Stable Identifier
R-HSA-8851859
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET activates RAS signaling (Homo sapiens)
Activated MET binds RANBP9 and SOS1 (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RANBP9 binds to activated MET receptor and recruits RAS guanyl nucleotide exchange factor SOS1. RANBP9 can associate with unphosphorylated MET, but has a higher affinity for the activated receptor. The interaction involves the sprouty (SPRY) domain of RANBP9 and the tyrosine kinase domain of MET (Wang et al. 2002). RANBP9 competes with RANBP10 for MET binding. RANBP10 does not interact with SOS1, and RANBP10 binding inhibits activation of RAS downstream of MET (Wang et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
14684163
A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling
Wang, D
,
Schoen, SR
,
Li, Z
,
Messing, EM
,
Wu, G
Biochem. Biophys. Res. Commun.
2004
12147692
Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM
Wang, D
,
Li, Z
,
Messing, EM
,
Wu, G
J. Biol. Chem.
2002
Participants
Input
HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]
(Homo sapiens)
RANBP9 [cytosol]
(Homo sapiens)
SOS1 [cytosol]
(Homo sapiens)
Output
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
MET activates RAS signaling (Homo sapiens)
This event is regulated
Negatively by
Regulator
HGF:p-4Y-MET dimer:RANBP10 [plasma membrane]
(Homo sapiens)
Active Unit
RANBP10 [cytosol]
Orthologous Events
Activated MET binds RANBP9 and SOS1 (Bos taurus)
Activated MET binds RANBP9 and SOS1 (Canis familiaris)
Activated MET binds RANBP9 and SOS1 (Mus musculus)
Activated MET binds RANBP9 and SOS1 (Rattus norvegicus)
Activated MET binds RANBP9 and SOS1 (Sus scrofa)
Activated MET binds RANBP9 and SOS1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2016-06-14)
Reviewed
Birchmeier, W (2016-07-11)
Heynen, G (2016-07-11)
Created
Orlic-Milacic, M (2016-01-12)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text