MUC20 (mucin 20) binds to both unphosphorylated and phosphorylated MET. MUC20 does not interfere with MET ligand-binding, dimerization and autophosphorylation, but association of MUC20 with activated MET specifically interferes with GRB2-1 recruitment to MET and the consequent RAS signaling activation. MUC20 oligomerization may facilitate binding to MET (Higuchi et al. 2004).
Nakamura, M, Orita, T, Li, H, Akiyama, K, Yamasaki, Y, Higuchi, T, Katsuya, K, Saito, Y, Yamamoto, T
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