MUC20 binds MET and inhibits GRB2 binding

Stable Identifier
R-HSA-8851842
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MUC20 (mucin 20) binds to both unphosphorylated and phosphorylated MET. MUC20 does not interfere with MET ligand-binding, dimerization and autophosphorylation, but association of MUC20 with activated MET specifically interferes with GRB2-1 recruitment to MET and the consequent RAS signaling activation. MUC20 oligomerization may facilitate binding to MET (Higuchi et al. 2004).

Literature References
PubMed ID Title Journal Year
15314156 MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met

Higuchi, T, Orita, T, Katsuya, K, Yamasaki, Y, Akiyama, K, Li, H, Yamamoto, T, Saito, Y, Nakamura, M

Mol. Cell. Biol. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed