Reactome | MUC20 binds MET and inhibits GRB2 binding

MUC20 binds MET and inhibits GRB2 binding

Stable Identifier

R-HSA-8851842

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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MUC20 binds MET and inhibits GRB2 binding

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MUC20 (mucin 20) binds to both unphosphorylated and phosphorylated MET. MUC20 does not interfere with MET ligand-binding, dimerization and autophosphorylation, but association of MUC20 with activated MET specifically interferes with GRB2-1 recruitment to MET and the consequent RAS signaling activation. MUC20 oligomerization may facilitate binding to MET (Higuchi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15314156	MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met Nakamura, M, Orita, T, Li, H, Akiyama, K, Yamasaki, Y, Higuchi, T, Katsuya, K, Saito, Y, Yamamoto, T	Mol. Cell. Biol.	2004