Reactome | RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1

RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1

Stable Identifier

R-HSA-8851827

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1

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GRB2-1 is an adaptor protein for the RAS guanyl nucleotide exchange factor SOS1. GRB2-1, through association with activated receptor tyrosine kinases, such as MET, mediates recruitment of SOS1 to the plasma membrane. At the plasma membrane, SOS1 catalyzes guanyl nucleotide exchange on RAS proteins from GDP to GTP, resulting in RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9070211	DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells Shen, K, Novak, RF	Biochem. Biophys. Res. Commun.	1997
9038378	Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2 Bardelli, A, Comoglio, PM, Besser, D, Thelen, M, Nagamine, Y, Ponzetto, C, Didichenko, S	Oncogene	1997