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HECW2 [cytosol]
Stable Identifier
R-HSA-8851656
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase HECW2 ecNumber6.3.2.-/ecNumber, HECW2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECW2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P2P5 HECW2
Gene Names
HECW2, KIAA1301, NEDL2
Chain
chain:1-1572
Reference Genes
BioGPS Gene:57520 HECW2
COSMIC (genes):HECW2 HECW2
CTD Gene:57520 HECW2
dbSNP Gene:57520 HECW2
ENSEMBL:ENSG00000138411 HECW2
HGNC:29853 HECW2
KEGG Gene (Homo sapiens):57520 HECW2
Monarch:57520 HECW2
NCBI Gene:57520 HECW2
OMIM:617245 HECW2
UCSC:Q9P2P5 HECW2
Reference Transcript
RefSeq:XM_017004563.1 HECW2
RefSeq:NM_020760.2 HECW2
Other Identifiers
0001170161
11730579_a_at
11730580_s_at
11730581_a_at
16906749
232080_at
236089_at
2593210
2593211
2593212
2593214
2593216
2593218
2593220
2593221
2593222
2593223
2593231
2593234
2593235
2593236
2593237
2593238
2593239
2593242
2593243
2593244
2593245
2593246
2593247
2593248
2593249
2593256
2593258
2593260
2593261
2593263
2593265
2593266
2593267
2593268
2593270
2593271
2593273
2593274
2593278
2593287
2593294
2593297
2593298
2593299
2593313
2593325
2593326
2593328
48275_at
57520
63528_at
73005_at
8057898
A_23_P50974
A_32_P17917
A_33_P3270311
GE53892
GE57452
GO:0000209
GO:0000278
GO:0000902
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005819
GO:0005856
GO:0006464
GO:0006511
GO:0006810
GO:0007049
GO:0007059
GO:0008150
GO:0009056
GO:0016567
GO:0016740
GO:0030071
GO:0030154
GO:0043161
GO:0043226
GO:0045732
GO:0048814
GO:0048856
GO:0051276
GO:0055085
GO:0061630
GO:0072686
GO:0140014
GO:2000650
Hs.22245.0.A1_3p_at
Hs.8707.0.S1_3p_at
ILMN_1775268
PH_hs_0023061
TC02002638.hg
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
Inferred To
pub1 [cytosol] (Schizosaccharomyces pombe)
RSP5 [cytosol] (Saccharomyces cerevisiae)
Homologues of HECW2 [cytosol] (Dictyostelium discoideum)
Homologues of HECW2 [cytosol] (Schizosaccharomyces pombe)
hecw-1 [cytosol] (Caenorhabditis elegans)
HECW2 [cytosol] (Bos taurus)
HECW2 [cytosol] (Canis familiaris)
HECW2 [cytosol] (Dictyostelium discoideum)
HECW2 [cytosol] (Gallus gallus)
HECW2 [cytosol] (Plasmodium falciparum)
HECW2 [cytosol] (Sus scrofa)
Hecw2 [cytosol] (Mus musculus)
Hecw2 [cytosol] (Rattus norvegicus)
pub3 [cytosol] (Schizosaccharomyces pombe)
pub2 [cytosol] (Schizosaccharomyces pombe)
CG3003 [cytosol] (Drosophila melanogaster)
hecw2a [cytosol] (Danio rerio)
Cross References
RefSeq
NP_065811.1
,
XP_016860052.1
OpenTargets
ENSG00000138411
HPA
ENSG00000138411-HECW2
GeneCards
Q9P2P5
Ensembl
ENST00000644256
,
ENST00000260983
,
ENST00000647236
,
ENST00000644978
,
ENSG00000138411
,
ENSP00000260983
,
ENSP00000495418
,
ENSP00000494800
,
ENSP00000494649
PRO
Q9P2P5
Orphanet
28192
PDB
2LFE
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