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HERC1 [cytosol]
Stable Identifier
R-HSA-8851655
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable E3 ubiquitin-protein ligase HERC1 ecNumber6.3.2.-/ecNumber, HERC1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15751 HERC1
Gene Names
HERC1
Chain
chain:1-4861
Reference Genes
BioGPS Gene:8925 HERC1
COSMIC (genes):HERC1 HERC1
CTD Gene:8925 HERC1
dbSNP Gene:8925 HERC1
ENSEMBL:ENSG00000103657 HERC1
HGNC:4867 HERC1
KEGG:hsa:8925 HERC1
Monarch:8925 HERC1
NCBI Gene:8925 HERC1
OMIM:605109 HERC1
UCSC:Q15751 HERC1
Reference Transcript
RefSeq:NM_003922.3 HERC1
Other Identifiers
11744225_at
11752299_a_at
16810376
218306_PM_s_at
218306_s_at
240703_PM_s_at
240703_s_at
3628651
3628652
3628653
3628657
3628658
3628660
3628661
3628665
3628666
3628667
3628668
3628669
3628670
3628671
3628672
3628673
3628674
3628676
3628677
3628679
3628680
3628681
3628683
3628685
3628686
3628688
3628689
3628690
3628691
3628692
3628693
3628696
3628697
3628698
3628699
3628700
3628701
3628702
3628704
3628705
3628706
3628707
3628708
3628709
3628710
3628712
3628713
3628715
3628716
3628718
3628720
3628721
3628722
3628723
3628724
3628726
3628727
3628730
3628732
3628733
3628735
3628736
3628737
3628738
3628739
3628740
3628741
3628742
3628743
3628744
3628746
3628748
3628753
3628754
3628755
3628759
3628762
3628763
3628765
3628766
3628767
3628769
3628771
3628772
3628773
3628774
3628775
3628776
3628783
3628784
3628785
3628787
3628788
3628790
3628791
3628792
3628793
3628794
3628795
3628796
3628798
3628801
3628802
3628803
3628805
3628810
73392_at
73408_at
78445_at
7989516
8925
91668_at
A_23_P257503
GE59206
GO:0003824
GO:0004842
GO:0005085
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0006914
GO:0007420
GO:0010507
GO:0016020
GO:0016567
GO:0016740
GO:0021702
GO:0022038
GO:0030154
GO:0031175
GO:0043226
GO:0048856
GO:0050877
GO:0050885
GO:0098772
GO:0140096
HMNXSV003001315
HMNXSV003052269
Hs.133411.0.A1_3p_s_at
ILMN_1786211
PH_hs_0022506
PH_hs_0041171
TC15001544.hg
U50078_at
g4557025_3p_s_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Herc1 [cytosol]
(Mus musculus)
Herc1 [cytosol]
(Rattus norvegicus)
HERC1 [cytosol]
(Canis familiaris)
HERC1 [cytosol]
(Dictyostelium discoideum)
HERC1 [cytosol]
(Gallus gallus)
HERC1 [cytosol]
(Plasmodium falciparum)
Cross References
RefSeq
NP_003913.3
ENSEMBL
ENST00000443617
,
ENSP00000390158
OpenTargets
ENSG00000103657
IntEnz
2.3.2.26
HPA
ENSG00000103657-HERC1
PRO
Q15751
Pharos - Targets
Q15751
GlyGen
Q15751
Orphanet
HERC1
HMDB Protein
HMDBP08447
PDB
4O2W
,
4QT6
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4Z2 NEUROG3
1
NEUROG3 [nucleoplasm]
(R-HSA-189530)
0.527
3
UniProt:O95395 GCNT3
1
GCNT3 [Golgi membrane]
(R-HSA-914013)
0.527
2
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