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HERC4 [cytosol]
Stable Identifier
R-HSA-8851645
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable E3 ubiquitin-protein ligase HERC4 ecNumber6.3.2.-/ecNumber, HERC4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5GLZ8 HERC4
Gene Names
HERC4, KIAA1593
Chain
chain:1-1057
Reference Genes
BioGPS Gene:26091 HERC4
COSMIC (genes):HERC4 HERC4
CTD Gene:26091 HERC4
dbSNP Gene:26091 HERC4
ENSEMBL:ENSG00000148634 HERC4
HGNC:24521 HERC4
KEGG Gene (Homo sapiens):26091 HERC4
Monarch:26091 HERC4
NCBI Gene:26091 HERC4
OMIM:609248 HERC4
UCSC:Q5GLZ8 HERC4
Reference Transcript
RefSeq:NM_001278187.1 HERC4
RefSeq:NM_001278186.1 HERC4
RefSeq:NM_022079.2 HERC4
RefSeq:NM_001278185.1 HERC4
RefSeq:NM_015601.3 HERC4
Other Identifiers
0004280139
11724781_a_at
11724782_x_at
11751957_a_at
11758560_s_at
11759677_at
16714890
208055_s_at
225988_at
225989_at
232026_at
26091
3292449
3292450
3292451
3292452
3292453
3292454
3292457
3292460
3292461
3292462
3292464
3292467
3292469
3292471
3292481
3292488
3292489
3292490
3292491
3292492
3292493
3292494
3292506
3292507
3292509
3292510
3292511
3292512
3292514
3292515
3292516
3292523
3292524
3292525
3292527
3292528
3292529
3292530
3292531
3292533
3292536
52911_at
56751_at
59079_at
7933947
A_23_P202408
A_24_P346807
A_24_P936041
A_33_P3216994
GE82022
GE86824
GE906406
GO:0000003
GO:0001650
GO:0003674
GO:0004842
GO:0005575
GO:0005622
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0006464
GO:0007165
GO:0007283
GO:0008150
GO:0016567
GO:0016740
GO:0030154
GO:0043226
GO:0045879
HMNXSV003007127
HMNXSV003010927
HMNXSV003051654
Hs.11123.1.S1_3p_at
Hs.11123.1.S2_3p_at
Hs.96867.0.S1_3p_at
ILMN_1678922
ILMN_1770665
ILMN_2370160
TC10001341.hg
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
HERC4 [cytosol]
(Canis familiaris)
HERC4 [cytosol]
(Dictyostelium discoideum)
HERC4 [cytosol]
(Sus scrofa)
Herc4 [cytosol]
(Drosophila melanogaster)
Herc4 [cytosol]
(Mus musculus)
Herc4 [cytosol]
(Rattus norvegicus)
herc4 [cytosol]
(Danio rerio)
herc4 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001265116.1
,
NP_001265115.1
,
NP_056416.2
,
NP_001265114.1
,
NP_071362.1
OpenTargets
ENSG00000148634
HPA
ENSG00000148634-HERC4
GeneCards
Q5GLZ8
Ensembl
ENSG00000148634
,
ENST00000473533
,
ENSP00000277817
,
ENST00000373700
,
ENSP00000362804
,
ENSP00000416504
,
ENST00000395198
,
ENSP00000378624
,
ENSP00000423671
,
ENSP00000422383
,
ENST00000492996
,
ENST00000412272
,
ENST00000277817
PRO
Q5GLZ8
Pharos - Targets
Q5GLZ8
GlyGen
Q5GLZ8
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