Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RNF130 [cytosol]
Stable Identifier
R-HSA-8851643
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase RNF130 ecNumber6.3.2.-/ecNumber, GOLI_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF130 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86XS8 RNF130
Gene Names
RNF130
Chain
signal peptide:1-27, chain:28-419
Reference Genes
BioGPS Gene:55819 RNF130
COSMIC (genes):RNF130 RNF130
CTD Gene:55819 RNF130
dbSNP Gene:55819 RNF130
ENSEMBL:ENSG00000113269 RNF130
HGNC:18280 RNF130
KEGG:hsa:55819 RNF130
Monarch:55819 RNF130
NCBI Gene:55819 RNF130
OMIM:619163 RNF130
UCSC:Q86XS8 RNF130
Reference Transcript
RefSeq:NM_018434.5 RNF130
RefSeq:NM_001280801.1 RNF130
Other Identifiers
11715617_a_at
1559537_PM_at
1559537_at
17003858
217865_PM_at
217865_at
230932_PM_at
230932_at
232192_PM_at
232192_at
236292_PM_at
236292_at
2890383
2890384
2890385
2890386
2890387
2890388
2890389
2890390
2890391
2890392
2890393
2890394
2890395
2890396
2890397
2890398
2890399
2890400
2890401
2890402
2890408
2890410
2890412
2890414
2890424
2890425
2890427
2890428
2890429
2890434
2890435
2890436
2890438
2890443
2890447
2890448
2890449
2890470
2890479
2890485
2890486
2890487
47075_at
55767_at
55819
59208_at
8116372
83569_at
A_23_P41734
A_24_P614261
A_33_P3255544
A_33_P3671506
GE78969
GE825400
GE831203
GE85521
GO:0003824
GO:0004842
GO:0005737
GO:0006511
GO:0006915
GO:0012501
GO:0016020
GO:0016567
GO:0016740
GO:0046872
GO:0061630
GO:0140096
HMNXSV003007383
HMNXSV003015012
HMNXSV003029912
Hs.102737.1.S1_3p_a_at
Hs.144515.0.S1_3p_at
Hs.155718.0.A1_3p_at
Hs.8038.0.A1_3p_at
Hs2.354286.1.S1_3p_at
ILMN_1729294
ILMN_1860963
PH_hs_0008549
PH_hs_0017166
PH_hs_0029253
RNA147292|p0396_imsncRNA814
RNA147293|p0397_imsncRNA814
TC05002142.hg
TC05003383.hg
TC05003384.hg
g10092650_3p_a_at
g10092650_3p_x_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
RNF130 [cytosol]
(Bos taurus)
RNF130 [cytosol]
(Caenorhabditis elegans)
RNF130 [cytosol]
(Gallus gallus)
Rnf130 [cytosol]
(Mus musculus)
Rnf130 [cytosol]
(Rattus norvegicus)
gol [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001267730.1
,
NP_060904.2
ENSEMBL
ENST00000521389
,
ENSP00000430237
,
ENST00000261947
,
ENSP00000261947
OpenTargets
ENSG00000113269
IntEnz
2.3.2.27
HPA
ENSG00000113269-RNF130
PRO
Q86XS8
Pharos - Targets
Q86XS8
GlyGen
Q86XS8
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6UX41 BTNL8
1
BTNL8 [plasma membrane]
(R-HSA-8852007)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text