NTPDase8, encoded by the ENTPD8 gene, is an E-NTPDase family ectonucleotide phosphatase that, in the presence of Ca2+ or Mg2+, hydrolyzes NTPs to NMPs, via corresponding NDP intermediates. NTPDase8 is more efficient in hydrolyzing NTPs than NDPs. NTPDase8 provides the main ectonucleotide phosphatase activity in rat and porcine livers (Sevigny et al. 2000, Fausther et al. 2007).
Sévigny, J, Pelletier, J, Lecka, J, Dranoff, JA, Kukulski, F, Fausther, M, Lévesque, SA, Zimmermann, H
Csizmadia, E, Sévigny, J, Smith, RN, Robson, SC, Lemmens, R, Waelkens, E
nucleoside-triphosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]
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