Reactome | NTPDase8 hydrolyzes nucleoside triphosphates

NTPDase8 hydrolyzes nucleoside triphosphates

Stable Identifier

R-HSA-8851538

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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NTPDase8 hydrolyzes nucleoside triphosphates

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NTPDase8, encoded by the ENTPD8 gene, is an E-NTPDase family ectonucleotide phosphatase that, in the presence of Ca2+ or Mg2+, hydrolyzes NTPs to NMPs, via corresponding NDP intermediates. NTPDase8 is more efficient in hydrolyzing NTPs than NDPs. NTPDase8 provides the main ectonucleotide phosphatase activity in rat and porcine livers (Sevigny et al. 2000, Fausther et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
10681547	Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase Sévigny, J, Robson, SC, Waelkens, E, Csizmadia, E, Smith, RN, Lemmens, R	J. Biol. Chem.	2000
17095758	Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8 Fausther, M, Lecka, J, Kukulski, F, Lévesque, SA, Pelletier, J, Zimmermann, H, Dranoff, JA, Sévigny, J	Am. J. Physiol. Gastrointest. Liver Physiol.	2007