NTPDase8 hydrolyzes nucleoside triphosphates

Stable Identifier
R-HSA-8851538
Type
Reaction
Species
Homo sapiens
Compartment
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NTPDase8, encoded by the ENTPD8 gene, is an E-NTPDase family ectonucleotide phosphatase that, in the presence of Ca2+ or Mg2+, hydrolyzes NTPs to NMPs, via corresponding NDP intermediates. NTPDase8 is more efficient in hydrolyzing NTPs than NDPs. NTPDase8 provides the main ectonucleotide phosphatase activity in rat and porcine livers (Sevigny et al. 2000, Fausther et al. 2007).

Literature References
PubMed ID Title Journal Year
17095758 Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8

Sévigny, J, Pelletier, J, Lecka, J, Dranoff, JA, Kukulski, F, Fausther, M, Lévesque, SA, Zimmermann, H

Am. J. Physiol. Gastrointest. Liver Physiol. 2007
10681547 Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase

Csizmadia, E, Sévigny, J, Smith, RN, Robson, SC, Lemmens, R, Waelkens, E

J. Biol. Chem. 2000
Participants
Participates
Catalyst Activity

nucleoside-triphosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]

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