NTPDase8 hydrolyzes nucleoside triphosphates

Stable Identifier
R-HSA-8851538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NTPDase8, encoded by the ENTPD8 gene, is an E-NTPDase family ectonucleotide phosphatase that, in the presence of Ca2+ or Mg2+, hydrolyzes NTPs to NMPs, via corresponding NDP intermediates. NTPDase8 is more efficient in hydrolyzing NTPs than NDPs. NTPDase8 provides the main ectonucleotide phosphatase activity in rat and porcine livers (Sevigny et al. 2000, Fausther et al. 2007).

Literature References
PubMed ID Title Journal Year
10681547 Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase

Sévigny, J, Robson, SC, Waelkens, E, Csizmadia, E, Smith, RN, Lemmens, R

J. Biol. Chem. 2000
17095758 Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8

Fausther, M, Lecka, J, Kukulski, F, Lévesque, SA, Pelletier, J, Zimmermann, H, Dranoff, JA, Sévigny, J

Am. J. Physiol. Gastrointest. Liver Physiol. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside-triphosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created