Reactome | CFHR4 [extracellular region]

CFHR4 [extracellular region]

Stable Identifier

R-HSA-8851441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Complement factor H-related protein 4, FHR4_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Regulation of Complement cascade (Homo sapiens)
      - CFHR dimers bind C3b (Homo sapiens)
        
        CFHR dimers [extracellular region] (Homo sapiens)
        
        CFHR4 dimer [extracellular region] (Homo sapiens)
        
        CFHR4 [extracellular region] (Homo sapiens)
        
        Cell surface:C3b:CFHR dimers [plasma membrane] (Homo sapiens)
        
        CFHR dimers [extracellular region] (Homo sapiens)
        
        CFHR4 dimer [extracellular region] (Homo sapiens)
        
        CFHR4 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92496 CFHR4

Gene Names

CFHR4, CFHL4, FHR4

Chain

signal peptide:1-19, chain:20-578

Reference Genes

BioGPS Gene:10877 CFHR4

COSMIC (genes):CFHR4 CFHR4

CTD Gene:10877 CFHR4

dbSNP Gene:10877 CFHR4

ENSEMBL:ENSG00000134365 CFHR4

ENSEMBL_homo_sapiens_GENE:ENSG00000134365.15 CFHR4

HGNC:16979 CFHR4

KEGG Gene (Homo sapiens):10877 CFHR4

Monarch:10877 CFHR4

NCBI Gene:10877 CFHR4

OMIM:605337 CFHR4

UCSC:Q92496 CFHR4

Reference Transcript

Other Identifiers

10877

11742140_a_at

11749157_s_at

11755723_s_at

16675457

207874_PM_s_at

207874_s_at

2373407

2373408

2373413

2373414

2373420

2373421

2373466

2373467

2373468

2373469

2373470

2373472

2373474

2373475

2373476

2373485

2373487

2373489

2373491

31591_s_at

7908492

8180222

A_24_P282547

GE80226

GO:0001851

GO:0002376

GO:0005215

GO:0005319

GO:0005515

GO:0005576

GO:0005615

GO:0006869

GO:0006956

HMNXSV003005805

HMNXSV003046586

ILMN_1665855

PH_hs_0032107

TC01006292.hg

X98337_s_at

g5729825_3p_s_at

Participates

as a component of

CFHR4 dimer [extracellular region] (Homo sapiens)

Inferred To

Cfhr2 [extracellular region] (Rattus norvegicus)

Homologues of CFHR4 [extracellular region] (Danio rerio)

Homologues of CFHR4 [extracellular region] (Mus musculus)

Homologues of CFHR4 [extracellular region] (Rattus norvegicus)

Homologues of CFHR4 [extracellular region] (Xenopus tropicalis)

Cfhr4 [extracellular region] (Mus musculus)

svep1l [extracellular region] (Xenopus tropicalis)

Cfhr1 [extracellular region] (Mus musculus)

si:ch211-207o17.7 [extracellular region] (Danio rerio)

LOC519737 [extracellular region] (Bos taurus)

f13b [extracellular region] (Xenopus tropicalis)

Cfh [extracellular region] (Mus musculus)

Cfh [extracellular region] (Rattus norvegicus)

CFHR4 [extracellular region] (Canis familiaris)

CFHR4 [extracellular region] (Gallus gallus)

si:ch211-207o17.2 [extracellular region] (Danio rerio)

zgc:101554 [extracellular region] (Danio rerio)

ENSRNOG00000066867 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_006675.2, NP_001188479.1, NP_001188480.1

OpenTargets

ENSG00000134365

GeneCards

Q92496

HPA

ENSG00000134365-CFHR4

Ensembl

ENSP00000356386, ENST00000367416, ENSG00000134365, ENSP00000251424, ENST00000608469, ENST00000251424, ENSP00000477162

PRO

Q92496

Pharos - Targets

Q92496

Orphanet

25065

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