NTPDase4 hydrolyzes nucleoside triphosphates

Stable Identifier
R-HSA-8851234
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen, Golgi membrane
Synonyms
UTP + H2O => UDP + phosphate + H(+), CTP + H2O => CDP + phosphate + H(+), GTP + H2O => GDP + phosphate + H(+), dTTP + H2O => dTDP + phosphate + H(+)
ReviewStatus
5/5
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NTPDase4 hydrolyzes nucleoside triphosphates
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NTPDase4 (UDPase), encoded by the ENTPD4 gene, is an E-NTPDase family member that localizes to the Golgi membrane and can hydrolyze nucleoside triphosphates UTP, GTP, CTP and TTP to nucleoside diphosphates UDP, GDP, CDP and TDP, respectively, in the Golgi lumen. NTPDase4 hydrolyzes nucleoside triphosphates less efficiently than nucleoside diphosphates. Ca2+ is needed for NTPDase4 activity (Wang and Guidotti 1998).
Literature References
PubMed ID Title Journal Year
9556635 Golgi localization and functional expression of human uridine diphosphatase

Wang, TF, Guidotti, G

J. Biol. Chem. 1998
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Catalyst Activity

ribonucleoside triphosphate phosphatase activity of NTPDase4:Ca2+ [Golgi membrane]

Physical Entity
NTPDase4:Ca2+ [Golgi membrane] (Homo sapiens)
Activity
ribonucleoside triphosphate phosphatase activity (GO:0017111)
Orthologous Events
NTPDase4 hydrolyzes nucleoside triphosphates (Bos taurus)
NTPDase4 hydrolyzes nucleoside triphosphates (Caenorhabditis elegans)
NTPDase4 hydrolyzes nucleoside triphosphates (Canis familiaris)
NTPDase4 hydrolyzes nucleoside triphosphates (Gallus gallus)
NTPDase4 hydrolyzes nucleoside triphosphates (Mus musculus)
NTPDase4 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)
NTPDase4 hydrolyzes nucleoside triphosphates (Rattus norvegicus)
NTPDase4 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)
NTPDase4 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)
NTPDase4 hydrolyzes nucleoside triphosphates (Sus scrofa)
NTPDase4 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)
Cross References
RHEA
Authored
Orlic-Milacic, M  (2015-12-30)
Reviewed
Sévigny, J  (2016-05-11)
Created
Orlic-Milacic, M  (2016-01-06)
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