NTPDase4 hydrolyzes nucleoside triphosphates

Stable Identifier
R-HSA-8851234
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NTPDase4 (UDPase), encoded by the ENTPD4 gene, is an E-NTPDase family member that localizes to the Golgi membrane and can hydrolyze nucleoside triphosphates UTP, GTP, CTP and TTP to nucleoside diphosphates UDP, GDP, CDP and TDP, respectively, in the Golgi lumen. NTPDase4 hydrolyzes nucleoside triphosphates less efficiently than nucleoside diphosphates. Ca2+ is needed for NTPDase4 activity (Wang and Guidotti 1998).

Literature References
PubMed ID Title Journal Year
9556635 Golgi localization and functional expression of human uridine diphosphatase

Wang, TF, Guidotti, G

J. Biol. Chem. 1998
Participants
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Catalyst Activity
Catalyst Activity
Title
nucleoside-triphosphatase activity of NTPDase4:Ca2+ [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created