Reactome | NTPDase3 hydrolyzes nucleoside diphosphates

NTPDase3 hydrolyzes nucleoside diphosphates

Stable Identifier

R-HSA-8851129

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

NTPDase3 hydrolyzes nucleoside diphosphates

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NTPDase3 (CD39L3), encoded by the ENTPD3 gene, is a plasma membrane-bound ectonucleotidase that hydrolyzes extracellular NDPs to corresponding NMPs (Smith and Kirley 1998, Lavoie et al. 2004, Vorhoff et al. 2005, Kukulski et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15130768	Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3 Lecka, J, Sévigny, J, Kukulski, F, Lavoie, EG, Lévesque, SA	Biochem. Pharmacol.	2004
18404504	Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 Lavoie, EG, Lévesque, SA, Sévigny, J, Kukulski, F, Kirley, TL, Robson, SC, Bigonnesse, F, Lecka, J, Knowles, AF	Purinergic Signal.	2005
18404510	Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin Pelletier, J, Sévigny, J, Vorhoff, T, Braun, N, Zimmermann, H	Purinergic Signal.	2005
9675246	Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1 Kirley, TL, Smith, TM	Biochim. Biophys. Acta	1998