NTPDase3 hydrolyzes nucleoside diphosphates

Stable Identifier
R-HSA-8851129
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NTPDase3 (CD39L3), encoded by the ENTPD3 gene, is a plasma membrane-bound ectonucleotidase that hydrolyzes extracellular NDPs to corresponding NMPs (Smith and Kirley 1998, Lavoie et al. 2004, Vorhoff et al. 2005, Kukulski et al. 2005).

Literature References
PubMed ID Title Journal Year
15130768 Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3

Lecka, J, Sévigny, J, Kukulski, F, Lavoie, EG, Lévesque, SA

Biochem. Pharmacol. 2004
18404504 Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8

Lavoie, EG, Lévesque, SA, Sévigny, J, Kukulski, F, Kirley, TL, Robson, SC, Bigonnesse, F, Lecka, J, Knowles, AF

Purinergic Signal. 2005
18404510 Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin

Pelletier, J, Sévigny, J, Vorhoff, T, Braun, N, Zimmermann, H

Purinergic Signal. 2005
9675246 Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1

Kirley, TL, Smith, TM

Biochim. Biophys. Acta 1998
Participants
Participates
Catalyst Activity

nucleoside-diphosphatase activity of NTPDase3:Ca2+,Mg2+ [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!