NTPDase3 hydrolyzes nucleoside diphosphates

Stable Identifier
R-HSA-8851129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NTPDase3 (CD39L3), encoded by the ENTPD3 gene, is a plasma membrane-bound ectonucleotidase that hydrolyzes extracellular NDPs to corresponding NMPs (Smith and Kirley 1998, Lavoie et al. 2004, Vorhoff et al. 2005, Kukulski et al. 2005).

Literature References
PubMed ID Title Journal Year
18404504 Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8

Kukulski, F, Lévesque, SA, Lavoie, EG, Lecka, J, Bigonnesse, F, Knowles, AF, Robson, SC, Kirley, TL, Sévigny, J

Purinergic Signal. 2005
15130768 Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3

Lavoie, EG, Kukulski, F, Lévesque, SA, Lecka, J, Sévigny, J

Biochem. Pharmacol. 2004
18404510 Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin

Vorhoff, T, Zimmermann, H, Pelletier, J, Sévigny, J, Braun, N

Purinergic Signal. 2005
9675246 Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1

Smith, TM, Kirley, TL

Biochim. Biophys. Acta 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside-diphosphatase activity of NTPDase3:Ca2+,Mg2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created