NTPDase2 hydrolyzes nucleoside triphosphates

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NTPDase2 (CD39L1), encoded by the ENTPD2 gene, is an ectonucleoside triphosphate diphosphohydrolase that is expressed at the plasma membrane where it hydrolyzes extracellular nucleoside triphosphates (ATP, GTP, CTP, ITP, UTP) to the respective nucleoside diphosphate (ADP, GDP, CDP, IDP, UDP) in the presence of Ca2+ of Mg2+ ions. NTPDase2 is only marginally active in hydrolyzing nucleoside diphosphates, such as ADP and UDP (Kegel et al. 1997, Kirley et al. 1997, Mateo et al. 1999). The alpha splicing isoform of NTPDase2 is expressed at the plasma membrane, while beta and gamma isoforms are expressed in the endoplasmic reticulum (Mateo et al. 2003). NTPDase2 may oligomerize and the oligomerization state may affect substrate specificity (Failer et al. 2003).

NTPDase2 may contribute to vascular hemostasis by exerting an opposing role to NTPDase1 (Sévigny et al. 2002).

Literature References
PubMed ID Title Journal Year
8995405 Complementary DNA cloning and sequencing of the chicken muscle ecto-ATPase. Homology with the lymphoid cell activation antigen CD39

Kirley, TL

J. Biol. Chem. 1997
11929769 Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation

Qawi, I, Sévigny, J, Imai, M, Robson, SC, Guckelberger, O, Sundberg, C, Braun, N, Zimmermann, H, Csizmadia, E

Blood 2002
9364474 An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain

Braun, N, Heine, P, Kegel, B, Zimmermann, H, Maliszewski, CR

Neuropharmacology 1997
12888562 Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme

Kreda, S, Boyer, JL, Mateo, J, Harden, TK, Henry, CE

J. Biol. Chem. 2003
10510450 Functional expression of a cDNA encoding a human ecto-ATPase

Boyer, JL, Harden, TK, Mateo, J

Br. J. Pharmacol. 1999
12694193 Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes

Schmalzing, G, Aschrafi, A, Failer, BU, Zimmermann, H

Eur. J. Biochem. 2003
Catalyst Activity

nucleoside-triphosphatase activity of NTPDase2:Ca2+,Mg2+ [plasma membrane]

Orthologous Events
Cite Us!