BTN3A1 binds prenylated phosphoantigens

Stable Identifier
Reaction [binding]
Homo sapiens
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Butyrophilin 3A1 (BTN3A1) directly binds to small pyrophosphate containing organic molecules known as prenyl pyrophosphates or phosphoantigens (pAgs). These molecules are produced either endogenously, such as isopentenyl pyrophosphate (IPP), an intermediate of the mevalonate pathway in human cells that can accumulate intracellularly during tumorigenesis, or by microbes, such as hydroxy-methyl-butyl-pyrophosphate (HDMAPP, also known as HMBPP), a microbial intermediate of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. This interaction causes a conformational change in the extracellular domain of BTN3A1, which then leads to the activation of a specialized subset of gamma/delta T cells Vgamma9Vdelta2. The other two members of the BTN3A family, BTN3A2 and BTN3A3 may also be involved in the activation process (Sandstrom et al. 2014).

Literature References
PubMed ID Title Journal Year
25657647 Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells

Gu, S, Nawrocka, W, Adams, EJ

Front Immunol 2014
24703779 The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells

Konczak, F, Scotet, E, Sandstrom, A, Léger, A, Adams, EJ, Peigné, CM, Gesnel, MC, Bonneville, M, Breathnach, R, Crooks, JE

Immunity 2014
Orthologous Events
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