Butyrophilin 2A1 (BTN2A1) can bind to a lectin molecule, DC-specific ICAM3-grabbing non-integrin (DC-SIGN; also known as CD209), found on monocytes and dendritic cells. Binding of DC-SIGN is dependent on the tumor- and/or tissue-specific high-mannose glycosylation of BTN2A1 (Malcherek et al. 2007). BTN2A1 may represent a susceptibility gene for metabolic syndrome and myocardial infarction through an effect on dyslipidaemia (Fujimaki et al. 2011, Hiramatsu et al. 2012, Yamada et al. 2011, Arnett & Viney 2014).