BTN2A1 binds DC-SIGN

Stable Identifier
R-HSA-8851018
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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BTN2A1 binds DC-SIGN
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Butyrophilin 2A1 (BTN2A1) can bind to a lectin molecule, DC-specific ICAM3-grabbing non-integrin (DC-SIGN; also known as CD209), found on monocytes and dendritic cells. Binding of DC-SIGN is dependent on the tumor- and/or tissue-specific high-mannose glycosylation of BTN2A1 (Malcherek et al. 2007). BTN2A1 may represent a susceptibility gene for metabolic syndrome and myocardial infarction through an effect on dyslipidaemia (Fujimaki et al. 2011, Hiramatsu et al. 2012, Yamada et al. 2011, Arnett & Viney 2014).
Literature References
PubMed ID Title Journal Year
17785817 The B7 homolog butyrophilin BTN2A1 is a novel ligand for DC-SIGN

Malcherek, G, Rhodes, D, Roda-Navarro, P, Mayr, L, Miller, N, Trowsdale, J

J. Immunol. 2007
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Authored
Garapati, P V  (2016-01-05)
Reviewed
Reith, W  (2016-09-09)
Rhodes, DA  (2017-03-01)
Created
Garapati, P V  (2016-01-05)
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