TRIM27 polyubiquitinates PTEN

Stable Identifier
R-HSA-8851011
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TRIM27 (RFP) is an E3 ubiquitin ligase for PTEN. TRIM27 polyubiquitinates PTEN on multiple lysines in the C2 domain of PTEN using K27-linkage between ubiquitin molecules. TRIM27-mediated ubiquitination inhibits PTEN lipid phosphatase activity, but does not affect PTEN protein localization or stability (Lee et al. 2013).

Literature References
PubMed ID Title Journal Year
23419514 RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

Lee, JT, Shan, J, Zhong, J, Li, M, Zhou, B, Zhou, A, Parsons, R, Gu, W

Cell Res. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of PTEN:TRIM27 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created