Proteasome degrades polyubiquitinated PTEN

Stable Identifier
Reaction [omitted]
Homo sapiens
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PTEN, polyubiquitinated by either NEDD4 (Wang et al. 2007), STUB1 (CHIP) (Ahmed et al. 2011), WWP2 (Maddika et al. 2011), XIAP (Van Themsche et al. 2009), MKRN1 (Lee et al. 2015) or RNF146 (Li et al. 2015), is degraded by the proteasome.

Literature References
PubMed ID Title Journal Year
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Van Themsche, C, Parent, S, Leblanc, V, Asselin, E

J. Biol. Chem. 2009
21532586 WWP2 is an E3 ubiquitin ligase for PTEN

Pokorny, JL, Palicharla, VR, Kavela, S, Chen, J, Maddika, S, Rani, N, Sarkaria, JN

Nat. Cell Biol. 2011
26183061 PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

Hewitt, SM, Han, HJ, Lee, MS, Lee, C, Chung, JY, Kim, JH, Jeong, MH, Ko, A, Cho, H, Lee, HW, Song, J, Chun, KH

Nat Commun 2015
22427670 The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation

Paul, I, Mandal, T, Chatterjee, U, Ahmed, SF, Ghosh, MK, Chatterjee, A, Deb, S

J. Biol. Chem. 2012
17218260 NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Pandolfi, PP, Cordon-Cardo, C, Trotman, LC, Gao, Z, Wang, J, Chen, Z, Wang, X, Jiang, X, Koppie, T, Tempst, P, Alimonti, A, Erdjument-Bromage, H

Cell 2007
25547115 Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

Yang, L, Lin, C, Wang, W, Li, N, Chen, J, Songyang, Z, Feng, L, Zhang, Y, Liang, K, Wang, J, Yu, Y, Han, X

Genes Dev. 2015
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
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