Proteasome degrades polyubiquitinated PTEN

Stable Identifier
R-HSA-8850992
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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PTEN, polyubiquitinated by either NEDD4 (Wang et al. 2007), STUB1 (CHIP) (Ahmed et al. 2011), WWP2 (Maddika et al. 2011), XIAP (Van Themsche et al. 2009), MKRN1 (Lee et al. 2015) or RNF146 (Li et al. 2015), is degraded by the proteasome.

Literature References
PubMed ID Title Journal Year
21532586 WWP2 is an E3 ubiquitin ligase for PTEN

Maddika, S, Kavela, S, Rani, N, Palicharla, VR, Pokorny, JL, Sarkaria, JN, Chen, J

Nat. Cell Biol. 2011
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Van Themsche, C, Leblanc, V, Parent, S, Asselin, E

J. Biol. Chem. 2009
26183061 PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

Lee, MS, Jeong, MH, Lee, HW, Han, HJ, Ko, A, Hewitt, SM, Kim, JH, Chun, KH, Chung, JY, Lee, C, Cho, H, Song, J

Nat Commun 2015
22427670 The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation

Ahmed, SF, Deb, S, Paul, I, Chatterjee, A, Mandal, T, Chatterjee, U, Ghosh, MK

J. Biol. Chem. 2012
17218260 NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Wang, X, Trotman, LC, Koppie, T, Alimonti, A, Chen, Z, Gao, Z, Wang, J, Erdjument-Bromage, H, Tempst, P, Cordon-Cardo, C, Pandolfi, PP, Jiang, X

Cell 2007
25547115 Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

Li, N, Zhang, Y, Han, X, Liang, K, Wang, J, Feng, L, Wang, W, Songyang, Z, Lin, C, Yang, L, Yu, Y, Chen, J

Genes Dev. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created