PREX2 binds PTEN and inhibits it

Stable Identifier
R-HSA-8850961
Type
Reaction [binding]
Species
Homo sapiens
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PREX2, a RAC1 guanine nucleotide exchange factor (GEF), binds to PTEN and inhibits its catalytic activity, resulting in enhanced PI3K/AKT signaling (Fine et al. 2009). The interaction involves the inositol polyphosphate 4-phosphatase domain and the pleckstrin homology (PH) domain of PREX2 and the PDZ binding domain, the phosphatase domain and the C2 domain of PTEN (Fine et al. 2009, Hodakoski et al. 2014). PREX2 binds both the unphosphorylated PTEN and PTEN phosphorylated at the C-terminal tail by casein kinase II, but inhibits the lipid phosphatase activity of phosphorylated PTEN only (Hodakoski et al. 2014). The GEF activity of PREX2 is not needed for PTEN inhibition (Fine et al. 2009).

PREX2 is frequently overexpressed in breast and prostate cancer (Fine et al. 2009) and mutated in melanoma (Berger et al. 2012).

Literature References
PubMed ID Title Journal Year
19729658 Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

Fine, B, Hodakoski, C, Koujak, S, Su, T, Saal, LH, Maurer, M, Hopkins, B, Keniry, M, Sulis, ML, Mense, S, Hibshoosh, H, Parsons, R

Science 2009
24367090 Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis

Hodakoski, C, Hopkins, BD, Barrows, D, Mense, SM, Keniry, M, Anderson, KE, Kern, PA, Hawkins, PT, Stephens, LR, Parsons, R

Proc. Natl. Acad. Sci. U.S.A. 2014
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