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HECTD2 [cytosol]
Stable Identifier
R-HSA-8850907
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable E3 ubiquitin-protein ligase HECTD2 ecNumber6.3.2.-/ecNumber, HECD2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HECTD2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5U5R9 HECTD2
Gene Names
HECTD2
Chain
chain:1-776
Reference Genes
BioGPS Gene:143279 HECTD2
COSMIC (genes):HECTD2 HECTD2
CTD Gene:143279 HECTD2
dbSNP Gene:143279 HECTD2
ENSEMBL:ENSG00000165338 HECTD2
HGNC:26736 HECTD2
KEGG:hsa:143279 HECTD2
Monarch:143279 HECTD2
NCBI Gene:143279 HECTD2
UCSC:Q5U5R9 HECTD2
Reference Transcript
RefSeq:NM_182765.5 HECTD2
RefSeq:NM_173497.3 HECTD2
RefSeq:NM_001284274.2 HECTD2
Other Identifiers
11715294_s_at
11729394_a_at
11729395_s_at
11759435_at
143279
1565699_PM_at
1565699_at
16707343
227568_PM_at
227568_at
238803_PM_at
238803_at
3257751
3257752
3257753
3257754
3257755
3257761
3257762
3257765
3257766
3257767
3257768
3257769
3257770
3257771
3257773
3257775
3257776
3257777
3257778
3257779
3257780
3257781
3257782
3257783
3257784
3257785
3257787
3257789
3257790
3257791
3257792
3257794
3257795
3257796
3257797
3257799
3257800
3257801
3257802
3257803
3257804
45432_r_at
47810_at
51029_at
62592_at
7929145
A_14_P115776
A_14_P121792
A_23_P355525
A_32_P201979
A_33_P3221341
A_33_P3221343
GE54864
GE571775
GO:0000209
GO:0003824
GO:0004842
GO:0005829
GO:0016567
GO:0016740
GO:0061630
GO:0140096
HMNXSV003009739
HMNXSV003013168
Hs.25320.0.S1_3p_at
Hs.66378.0.A1_3p_at
Hs2.208047.1.S1_3p_at
ILMN_1668876
ILMN_1726636
ILMN_1790530
PH_hs_0022172
TC10000653.hg
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
HUL4 [cytosol]
(Saccharomyces cerevisiae)
Hectd2 [cytosol]
(Mus musculus)
Hectd2 [cytosol]
(Rattus norvegicus)
mug30 [cytosol]
(Schizosaccharomyces pombe)
ube3a [cytosol]
(Dictyostelium discoideum)
HECTD2 [cytosol]
(Bos taurus)
HECTD2 [cytosol]
(Canis familiaris)
HECTD2 [cytosol]
(Gallus gallus)
HECTD2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_775768.3
,
NP_877497.3
,
NP_001271203.1
ENSEMBL
ENST00000298068
,
ENST00000371681
,
ENSP00000360746
,
ENSP00000298068
OpenTargets
ENSG00000165338
HPA
ENSG00000165338-HECTD2
PRO
Q5U5R9
Pharos - Targets
Q5U5R9
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