Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HERC6 [cytosol]
Stable Identifier
R-HSA-8850906
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Probable E3 ubiquitin-protein ligase HERC6 ecNumber6.3.2.-/ecNumber, HERC6_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
HERC6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IVU3 HERC6
Gene Names
HERC6
Chain
chain:1-1022
Reference Genes
BioGPS Gene:55008 HERC6
COSMIC (genes):HERC6 HERC6
CTD Gene:55008 HERC6
dbSNP Gene:55008 HERC6
ENSEMBL:ENSG00000138642 HERC6
HGNC:26072 HERC6
KEGG:hsa:55008 HERC6
Monarch:55008 HERC6
NCBI Gene:55008 HERC6
OMIM:609249 HERC6
UCSC:Q8IVU3 HERC6
Reference Transcript
RefSeq:NM_017912.3 HERC6
RefSeq:NM_001165136.1 HERC6
Other Identifiers
11723128_a_at
16968735
219352_PM_at
219352_at
2735363
2735368
2735370
2735371
2735372
2735373
2735374
2735376
2735377
2735378
2735379
2735380
2735381
2735382
2735383
2735384
2735386
2735388
2735389
2735392
2735394
2735395
2735396
2735397
2735399
2735400
2735401
2735402
2735403
2735404
2735405
2735406
2735407
2735408
2735485
55008
58957_at
8096335
A_14_P128191
A_23_P250353
A_23_P250358
A_33_P3315779
GE55582
GO:0002244
GO:0003824
GO:0004842
GO:0005654
GO:0005737
GO:0005829
GO:0006511
GO:0009617
GO:0016567
GO:0016740
GO:0030154
GO:0061630
GO:0140096
HMNXSV003032591
ILMN_1654639
PH_hs_0033366
TC04000484.hg
g8923589_3p_at
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
herc-1 [cytosol]
(Caenorhabditis elegans)
herc6 [cytosol]
(Xenopus tropicalis)
gacGG [cytosol]
(Dictyostelium discoideum)
glo-4 [cytosol]
(Caenorhabditis elegans)
Homologues of HERC6 [cytosol]
(Caenorhabditis elegans)
Homologues of HERC6 [cytosol]
(Dictyostelium discoideum)
tirA [cytosol]
(Dictyostelium discoideum)
HERC6 [cytosol]
(Bos taurus)
HERC6 [cytosol]
(Canis familiaris)
HERC6 [cytosol]
(Dictyostelium discoideum)
HERC6 [cytosol]
(Plasmodium falciparum)
HERC6 [cytosol]
(Sus scrofa)
Herc4 [cytosol]
(Drosophila melanogaster)
Herc6 [cytosol]
(Mus musculus)
Herc6 [cytosol]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000380265
,
ENST00000264346
,
ENSP00000264346
,
ENSG00000138642
,
ENSP00000369617
OpenTargets
ENSG00000138642
GeneCards
HERC6
HPA
ENSG00000138642-HERC6
PRO
Q8IVU3
Pharos - Targets
Q8IVU3
GlyGen
Q8IVU3
PDB
5W87
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text