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ZNRF2 [cytosol]
Stable Identifier
R-HSA-8850901
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase ZNRF2 ecNumber6.3.2.-/ecNumber, ZNRF2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
ZNRF2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NHG8 ZNRF2
Gene Names
ZNRF2, RNF202
Chain
initiator methionine:, chain:2-242
Reference Genes
BioGPS Gene:223082 ZNRF2
COSMIC (genes):ZNRF2 ZNRF2
CTD Gene:223082 ZNRF2
dbSNP Gene:223082 ZNRF2
ENSEMBL:ENSG00000180233 ZNRF2
HGNC:22316 ZNRF2
KEGG:hsa:223082 ZNRF2
Monarch:223082 ZNRF2
NCBI Gene:223082 ZNRF2
OMIM:612061 ZNRF2
UCSC:Q8NHG8 ZNRF2
Reference Transcript
RefSeq:NM_147128.3 ZNRF2
Other Identifiers
11743635_at
17044793
223082
226261_PM_at
226261_at
2995125
2995126
2995127
2995128
2995129
2995130
2995131
2995132
2995133
2995134
2995135
2995136
2995137
2995140
2995146
2995154
2995155
2995156
2995319
2995321
2996110
2996112
3043846
3043850
3254322
60835_at
8132062
91088_at
A_23_P325017
A_33_P3312842
GE88659
GO:0001650
GO:0003824
GO:0005654
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0010008
GO:0016020
GO:0016567
GO:0016740
GO:0030163
GO:0030659
GO:0031410
GO:0032991
GO:0042734
GO:0042995
GO:0043161
GO:0043226
GO:0043231
GO:0045202
GO:0046872
GO:0061630
GO:0070936
GO:0140096
GO:0160177
HMNXSV003021305
Hs.127294.0.A1_3p_at
ILMN_1769503
PH_hs_0007301
TC07000195.hg
TC07003390.hg
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Znrf2 [cytosol]
(Mus musculus)
Znrf2 [cytosol]
(Rattus norvegicus)
znrf2 [cytosol]
(Danio rerio)
znrf2 [cytosol]
(Xenopus tropicalis)
ZNRF2 [cytosol]
(Bos taurus)
ZNRF2 [cytosol]
(Caenorhabditis elegans)
ZNRF2 [cytosol]
(Canis familiaris)
ZNRF2 [cytosol]
(Dictyostelium discoideum)
ZNRF2 [cytosol]
(Gallus gallus)
ZNRF2 [cytosol]
(Sus scrofa)
detr [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000323037
,
ENSG00000180233
,
ENSP00000323879
OpenTargets
ENSG00000180233
GeneCards
ZNRF2
HPA
ENSG00000180233-ZNRF2
PRO
Q8NHG8
Pharos - Targets
Q8NHG8
GlyGen
Q8NHG8
HMDB Protein
HMDBP09270
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61088 UBE2N
5
UBE2N [cytosol]
(R-HSA-206072)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
UBE2N [nucleoplasm]
(R-HSA-5682541)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
0.508
2
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