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UNKL [cytosol]
Stable Identifier
R-HSA-8850900
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Putative E3 ubiquitin-protein ligase UNKL ecNumber6.3.2.-/ecNumber, UNKL_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UNKL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H9P5 UNKL
Gene Names
UNKL, C16orf28, ZC3H5L, ZC3HDC5L
Chain
chain:1-680
Reference Genes
BioGPS Gene:64718 UNKL
COSMIC (genes):UNKL UNKL
CTD Gene:64718 UNKL
dbSNP Gene:64718 UNKL
ENSEMBL:ENSG00000059145 UNKL
ENSEMBL:ENSG00000059145.19 UNKL
HGNC:14184 UNKL
KEGG Gene (Homo sapiens):64718 UNKL
Monarch:64718 UNKL
NCBI Gene:64718 UNKL
OMIM:617463 UNKL
UCSC:Q9H9P5 UNKL
Reference Transcript
RefSeq:NM_001193389.1 UNKL
RefSeq:NM_001276414.1 UNKL
RefSeq:XM_017023568.1 UNKL
RefSeq:NM_001037125.3 UNKL
RefSeq:NM_001193388.3 UNKL
RefSeq:XM_017023569.1 UNKL
Other Identifiers
11724418_a_at
11736791_at
11752238_x_at
221064_PM_s_at
221064_s_at
229908_PM_s_at
229908_s_at
235087_PM_at
235087_at
3675834
3675835
3675836
3675837
3675839
3675841
3675842
3675843
3675845
3675846
3675847
3675848
3675850
3675851
3675852
3675853
3675854
3675855
3675874
3675876
3675877
3675878
3675881
3675884
3675885
3675889
3675890
3675892
3675893
64718
69596_at
76190_at
7998457
84145_at
A_24_P374675
GE769325
GE86450
GO:0003824
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0016567
GO:0016740
GO:0036211
GO:0043226
GO:0046872
HMNXSV003013722
HMNXSV003026872
Hs.118261.0.A1_3p_at
Hs.241575.1.A1_3p_at
ILMN_1692826
ILMN_2126408
PH_hs_0009794
PH_hs_0037669
g12751488_3p_x_at
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
unk [cytosol]
(Drosophila melanogaster)
unkl [cytosol]
(Xenopus tropicalis)
Unkl [cytosol]
(Mus musculus)
Unkl [cytosol]
(Rattus norvegicus)
unk-1 [cytosol]
(Caenorhabditis elegans)
UNKL [cytosol]
(Bos taurus)
UNKL [cytosol]
(Canis familiaris)
UNKL [cytosol]
(Danio rerio)
UNKL [cytosol]
(Gallus gallus)
UNKL [cytosol]
(Plasmodium falciparum)
UNKL [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016879057.1
,
NP_001180318.1
,
NP_001263343.1
,
NP_001032202.1
,
XP_016879058.1
,
NP_001180317.2
OpenTargets
ENSG00000059145
GeneCards
Q9H9P5
HPA
ENSG00000059145-UNKL
Ensembl
ENST00000301712
,
ENST00000674376
,
ENSP00000301712
,
ENST00000397464
,
ENST00000248104
,
ENSP00000248104
,
ENSP00000380606
,
ENSG00000059145
,
ENSP00000501444
PRO
Q9H9P5
Pharos - Targets
Q9H9P5
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.508
2
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