Reactome | UNKL [cytosol]

UNKL [cytosol]

Stable Identifier

R-HSA-8850900

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Putative E3 ubiquitin-protein ligase UNKL ecNumber6.3.2.-/ecNumber, UNKL_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H9P5 UNKL

Gene Names

UNKL, C16orf28, ZC3H5L, ZC3HDC5L

Chain

chain:1-680

Reference Genes

BioGPS Gene:64718 UNKL

COSMIC (genes):UNKL UNKL

CTD Gene:64718 UNKL

dbSNP Gene:64718 UNKL

ENSEMBL:ENSG00000059145 UNKL

HGNC:14184 UNKL

KEGG:hsa:64718 UNKL

Monarch:64718 UNKL

NCBI Gene:64718 UNKL

OMIM:617463 UNKL

UCSC:Q9H9P5 UNKL

Reference Transcript

Participates

as a member of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

unk [cytosol] (Drosophila melanogaster)

unkl [cytosol] (Danio rerio)

unkl [cytosol] (Xenopus tropicalis)

Unkl [cytosol] (Mus musculus)

Unkl [cytosol] (Rattus norvegicus)

unk-1 [cytosol] (Caenorhabditis elegans)

Homologues of UNKL [cytosol] (Plasmodium falciparum)

UNKL [cytosol] (Bos taurus)

UNKL [cytosol] (Canis familiaris)

UNKL [cytosol] (Gallus gallus)

UNKL [cytosol] (Plasmodium falciparum)

UNKL [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_047290451.1, XP_047290448.1, XP_047290449.1, XP_054169683.1, XP_054169680.1, NP_001263343.1, XP_016879057.1, NP_001032202.1, NP_001354551.1, XP_054169679.1, NP_001180317.2, NP_001180318.1, XP_054169682.1, XP_016879058.1, XP_047290450.1, XP_054169681.1

OpenTargets

ENSG00000059145

ENSEMBL

ENST00000301712, ENST00000248104, ENST00000397464, ENSP00000380606, ENSP00000501444, ENSG00000059145, ENST00000674376, ENSP00000248104, ENSP00000301712

HPA

ENSG00000059145-UNKL

GeneCards

UNKL

PRO

Q9H9P5

Pharos - Targets

Q9H9P5

GlyGen

Q9H9P5

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.508	2
UniProt:Q92925 SMARCD2	1	SMARCD2 [nucleoplasm] (R-HSA-5225626)	0.508	2

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