Reactome | KLK8 propeptide [extracellular region]

KLK8 propeptide [extracellular region]

Stable Identifier

R-HSA-8850829

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Kallikrein-8 propeptide

Locations in the PathwayBrowser for interactor UniProt:Q8IUH5 ZDH17

Expand all

Literature References

PubMed ID	Title	Journal	Year
20940292	Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade Eissa, A, Diamandis, EP, Amodeo, V, Smith, CR	J. Biol. Chem.	2011

External Reference Information

External Reference

UniProt:O60259 KLK8

Gene Names

KLK8, NRPN, PRSS19, TADG14, UNQ283/PRO322

Chain

signal peptide:1-28, propeptide:29-32, chain:33-260

Reference Genes

BioGPS Gene:11202 KLK8

COSMIC (genes):KLK8 KLK8

CTD Gene:11202 KLK8

dbSNP Gene:11202 KLK8

ENSEMBL:ENSG00000129455 KLK8

ENSEMBL_homo_sapiens_GENE:ENSG00000129455.16 KLK8

HGNC:6369 KLK8

KEGG Gene (Homo sapiens):11202 KLK8

Monarch:11202 KLK8

NCBI Gene:11202 KLK8

OMIM:605644 KLK8

UCSC:O60259 KLK8

Reference Transcript

Other Identifiers

11202

11731283_a_at

11731909_a_at

11742279_s_at

11742409_x_at

11755565_x_at

11763539_a_at

1552319_PM_a_at

1552319_a_at

16874713

206125_PM_s_at

206125_s_at

233687_PM_s_at

233687_s_at

37131_at

3868800

3868801

3868802

3868805

3868807

3868808

3868809

3868810

3868812

3868813

3868815

3868817

8038707

A_23_P369343

A_33_P3398195

GE533429

GE895735

GO:0003824

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0006508

GO:0007613

GO:0008233

GO:0008236

GO:0009611

GO:0016787

GO:0030141

GO:0030154

GO:0031410

GO:0034330

GO:0043226

GO:0043616

GO:0048812

GO:0048856

GO:0050807

GO:0050808

GO:0050877

GO:0097180

GO:0140096

HMNXSV003051581

HMNXSV003052825

Hs.302009.1.S1_3p_a_at

Hs2.104570.2.A1_3p_s_at

ILMN_1705252

ILMN_1735700

ILMN_2124425

PH_hs_0005801

g6005843_3p_s_at

Participates

as an output of

KLK5 cleaves and activates KLK8 (Homo sapiens)

Other forms of this molecule

proKLK8 [extracellular region]

KLK8 [extracellular region]

Inferred To

KLK8 propeptide [extracellular region] (Sus scrofa)

KLK8 [extracellular region] (Bos taurus)

KLK8 [extracellular region] (Canis familiaris)

Klk8 [extracellular region] (Mus musculus)

Klk8 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_653089.1, NP_009127.1, NP_653088.1, NP_001268360.1, NP_653090.1

Guide to Pharmacology - Targets

2378

OpenTargets

ENSG00000129455

IntEnz

3.4.21.118

GeneCards

O60259

HPA

ENSG00000129455-KLK8

ZINC target

O60259

Ensembl

ENSP00000469278, ENSP00000472016, ENSP00000341555, ENSG00000129455, ENSP00000375682, ENSP00000512260, ENST00000600767, ENST00000347619, ENST00000391806, ENST00000320838, ENST00000695909, ENST00000593490, ENSP00000325072

PRO

O60259

Pharos - Targets

O60259

PDB

5MS3, 5MS4

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q8IUH5 ZDH17			0.508	3

Cite Us!