G-protein alpha releases G-protein heterotrimer from PDCL

Stable Identifier
R-HSA-8850560
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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G-protein alpha associates with G-protein beta:gamma dimers bound to PDCL (PhLP1), resulting in release of the G-protein heterotrimer from PDCL co-chaperone (Lukov et al. 2005, Plimpton et al. 2015).

Literature References
PubMed ID Title Journal Year
25675501 Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly

Plimpton, RL, Cuellar, J, Lai, CW, Aoba, T, Makaju, A, Franklin, S, Mathis, AD, Prince, JT, Carrascosa, JL, Valpuesta, JM, Willardson, BM

Proc. Natl. Acad. Sci. U.S.A. 2015
15889144 Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly

Lukov, GL, Hu, T, McLaughlin, JN, Hamm, HE, Willardson, BM

EMBO J. 2005
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