RGS proteins bind GNB5 and CCT/TRiC

Stable Identifier
R-HSA-8850529
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RGS proteins RGS7, RGS9 and, probably RGS6 and RGS11, bind to folded G-protein beta 5 subunit (GNB5) associated with the CCT/TRiC chaperonin. A RGS protein can associate with GNB5 and CCT/TRiC only after PDCL (PhLP1) is released as PDCL and RGS protein interact with overlapping regions of GNB5 (Howlett et al. 2009, Tracy et al. 2015).

Literature References
PubMed ID Title Journal Year
25659125 Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling

Tracy, CM, Kolesnikov, AV, Blake, DR, Chen, CK, Baehr, W, Kefalov, VJ, Willardson, BM

PLoS ONE 2015
19376773 Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity

Howlett, AC, Gray, AJ, Hunter, JM, Willardson, BM

J. Biol. Chem. 2009
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