PDCL releases folded G-beta from TRiC/CCT

Stable Identifier
Reaction [dissociation]
Homo sapiens
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PDCL (PhLP1) enables completion of folding of G-protein beta subunits 1-4 (GNB1, GNB2, GNB3 and GNB4) by the TRiC/CCT chaperonin, resulting in the release of dimers of PDCL and folded G-protein beta 1-4 (Lukov et al. 2005, Lukov et al. 2006, Howlett et al. 2009, Plimpton et al. 2015).
Literature References
PubMed ID Title Journal Year
19376773 Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity

Gray, AJ, Hunter, JM, Howlett, AC, Willardson, BM

J. Biol. Chem. 2009
16717095 Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex

Thulin, CD, Lukov, GL, Ludtke, PJ, Hu, T, Carter, MD, Baker, CM, Hackett, RA, Willardson, BM

J. Biol. Chem. 2006
15889144 Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly

Lukov, GL, Hu, T, Hamm, HE, McLaughlin, JN, Willardson, BM

EMBO J. 2005
25675501 Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly

Makaju, A, Lai, CW, Prince, JT, Carrascosa, JL, Plimpton, RL, Cuellar, J, Valpuesta, JM, Aoba, T, Franklin, S, Willardson, BM, Mathis, AD

Proc. Natl. Acad. Sci. U.S.A. 2015
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