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SALM2 associate with AMPA and NMDA receptors
Stable Identifier
R-HSA-8849881
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SLAM2 binds AMPA and NMDA receptors
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Synaptic adhesion-like molecules (Homo sapiens)
SALM2 associate with AMPA and NMDA receptors (Homo sapiens)
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SALM2 coimmunoprecipitates with NMDAR and AMPAR subunits isolated from detergent-solubilized brain (Ko et al. 2006). SALM2 co localizes with both pre- and post-synaptic proteins at excitatory synapses in mature neurons. SALM2 associates with AMPA receptors and, to a lesser extent, with NMDA receptors in hippocampal cultures. SALM2 appears to promote the maturation, but not the formation, of excitatory synapses, in line with the fact that synaptic localization of AMPA receptors occurs at late stages of excitatory synaptic development (Ko et al. 2006, Nam et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
16630835
SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses
Kaang, BK
,
Kim, H
,
Kim, K
,
Chung, HS
,
Kim, E
,
Ko, J
,
Kim, S
,
Jun, H
,
Han, K
Neuron
2006
Participants
Input
AMPA, NMDA receptors [plasma membrane]
(Homo sapiens)
SALM2 [plasma membrane]
(Homo sapiens)
Output
SALM2:AMPA, NMDA receptors [plasma membrane]
(Homo sapiens)
Participates
as an event of
Synaptic adhesion-like molecules (Homo sapiens)
Orthologous Events
SALM2 associate with AMPA and NMDA receptors (Bos taurus)
SALM2 associate with AMPA and NMDA receptors (Caenorhabditis elegans)
SALM2 associate with AMPA and NMDA receptors (Canis familiaris)
SALM2 associate with AMPA and NMDA receptors (Danio rerio)
SALM2 associate with AMPA and NMDA receptors (Drosophila melanogaster)
SALM2 associate with AMPA and NMDA receptors (Gallus gallus)
SALM2 associate with AMPA and NMDA receptors (Mus musculus)
SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)
SALM2 associate with AMPA and NMDA receptors (Xenopus tropicalis)
Authored
Garapati, P V (2015-12-18)
Reviewed
Kim, E (2016-02-04)
Petralia, RS (2016-05-17)
Seabold, GK (2016-05-17)
Created
Garapati, P V (2015-12-18)
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