SALM2 coimmunoprecipitates with NMDAR and AMPAR subunits isolated from detergent-solubilized brain (Ko et al. 2006). SALM2 co localizes with both pre- and post-synaptic proteins at excitatory synapses in mature neurons. SALM2 associates with AMPA receptors and, to a lesser extent, with NMDA receptors in hippocampal cultures. SALM2 appears to promote the maturation, but not the formation, of excitatory synapses, in line with the fact that synaptic localization of AMPA receptors occurs at late stages of excitatory synaptic development (Ko et al. 2006, Nam et al. 2011).