Reactome | PSD-95 binds NMDA receptor

PSD-95 binds NMDA receptor

Stable Identifier

R-HSA-8849878

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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Many membrane proteins that contain a PDZ-binding domain require an interaction with a PDZ protein for correct targeting to the cell surface (Zheng et al. 2011). N-methyl-D-aspartate (NMDA) receptor interact with postsynaptic density protein (PSD-95) and the PSD-95 family might serve to anchor NMDA receptors to the submembrane cytoskeleton and aid in the assembly of signal transduction complexes at postsynaptic sites (Niethammer et al. 1996, Kornau et al. 1995, Sans et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
7569905	Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95 Kornau, HC, Schenker, LT, Kennedy, MB, Seeburg, PH	Science	1995
8601796	Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases Niethammer, M, Kim, E, Sheng, M	J. Neurosci.	1996