PSD-95 binds NMDA receptor

Stable Identifier
R-HSA-8849878
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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PSD-95 binds NMDA receptor
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Many membrane proteins that contain a PDZ-binding domain require an interaction with a PDZ protein for correct targeting to the cell surface (Zheng et al. 2011). N-methyl-D-aspartate (NMDA) receptor interact with postsynaptic density protein (PSD-95) and the PSD-95 family might serve to anchor NMDA receptors to the submembrane cytoskeleton and aid in the assembly of signal transduction complexes at postsynaptic sites (Niethammer et al. 1996, Kornau et al. 1995, Sans et al. 2000).
Literature References
PubMed ID Title Journal Year
8601796 Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

Sheng, M, Kim, E, Niethammer, M

J. Neurosci. 1996
7569905 Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

Schenker, LT, Kornau, HC, Seeburg, PH, Kennedy, MB

Science 1995
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Orthologous Events
PSD-95 binds NMDA receptor (Caenorhabditis elegans)
PSD-95 binds NMDA receptor (Canis familiaris)
PSD-95 binds NMDA receptor (Drosophila melanogaster)
PSD-95 binds NMDA receptor (Mus musculus)
PSD-95 binds NMDA receptor (Rattus norvegicus)
PSD-95 binds NMDA receptor (Sus scrofa)
Authored
Garapati, P V  (2015-12-18)
Reviewed
Kim, E  (2016-02-04)
Petralia, RS  (2016-05-17)
Seabold, GK  (2016-05-17)
Created
Garapati, P V  (2015-12-18)
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