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ST14 [plasma membrane]
Stable Identifier
R-HSA-8849787
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Suppressor of tumorigenicity 14 protein, Matriptase
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
Membrane profilaggrin processing proteases [plasma membrane] (Homo sapiens)
ST14 [plasma membrane] (Homo sapiens)
ST14 hydrolyzes and activates KLK5 (Homo sapiens)
ST14 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5Y6 ST14
Gene Names
ST14, PRSS14, SNC19, TADG15
Chain
chain:1-855
Reference Genes
BioGPS Gene:6768 ST14
COSMIC (genes):ST14 ST14
CTD Gene:6768 ST14
dbSNP Gene:6768 ST14
ENSEMBL:ENSG00000149418 ST14
HGNC:11344 ST14
Monarch:6768 ST14
NCBI Gene:6768 ST14
OMIM:606797 ST14
UCSC:Q9Y5Y6 ST14
Reference Transcript
RefSeq:NM_021978.3 ST14
Other Identifiers
11715965_at
11748085_a_at
16733473
202005_PM_at
202005_at
216905_PM_s_at
216905_s_at
3356176
3356177
3356184
3356185
3356186
3356187
3356188
3356189
3356190
3356191
3356192
3356193
3356194
3356195
3356196
3356198
3356202
3356204
3356206
3356209
3356210
3356211
35309_at
6768
75085_at
7945204
80534_r_at
A_14_P119469
A_23_P47282
GO:0001843
GO:0003824
GO:0004252
GO:0005515
GO:0005615
GO:0005886
GO:0006508
GO:0008236
GO:0009897
GO:0016020
GO:0016323
GO:0016787
GO:0030154
GO:0030163
GO:0030216
GO:0060672
GO:0140096
HMNXSV003023697
Hs.56937.1.S1_3p_a_at
ILMN_1699887
PH_hs_0003679
TC11001195.hg
Participates
as a member of
Membrane profilaggrin processing proteases [plasma membrane] (Homo sapiens)
Cross References
ZINC - World Drugs
ST14_HUMAN
Guide to Pharmacology - Targets
2418
OpenTargets
ENSG00000149418
ENSEMBL
ENST00000278742
,
ENSP00000278742
ZINC - FDA approved
ST14_HUMAN
ZINC - Substances
ST14_HUMAN
ZINC - Biogenic
ST14_HUMAN
ZINC target
Q9Y5Y6
PRO
Q9Y5Y6
GlyGen
Q9Y5Y6
PDB
3NCL
,
4ISN
,
4O9V
,
2GV7
,
4O97
,
4JZI
,
5LYO
,
4JYT
,
3P8G
,
4ISO
,
2GV6
,
3SO3
,
3P8F
,
4ISL
,
1EAW
,
6T9T
,
3BN9
,
4JZ1
,
1EAX
,
6N4T
,
4R0I
,
4IS5
,
8G1W
,
3NPS
ZINC - Investigational
ST14_HUMAN
HPA
ENSG00000149418-ST14
Pharos - Targets
Q9Y5Y6
Orphanet
ST14
ZINC - Predictions - Purchasable
ST14_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04721 NOTCH2
18
NOTCH2(1582-1665) [extracellular region]
(R-HSA-157652)
NOTCH2(1666-1696) [plasma membrane]
(R-HSA-157628)
NEXT2 [plasma membrane]
(R-HSA-157225)
NICD2 [cytosol]
(R-HSA-157642)
NICD2 [nucleoplasm]
(R-HSA-157942)
Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911428)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911417)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane]
(R-HSA-1911505)
18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane]
(R-HSA-1983676)
NOTCH2(1582-2471) [Golgi membrane]
(R-HSA-157017)
18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region]
(R-HSA-1983678)
NOTCH2(1582-2471) [plasma membrane]
(R-HSA-157228)
18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane]
(R-HSA-1472874)
18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane]
(R-HSA-1467379)
18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane]
(R-HSA-1467363)
Pre-NOTCH2 [endoplasmic reticulum membrane]
(R-HSA-157025)
FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane]
(R-HSA-1911520)
FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane]
(R-HSA-1911518)
0.547
2
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