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RGS5 [plasma membrane]
Stable Identifier
R-HSA-8849408
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 5, RGS5_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15539 RGS5
Gene Names
RGS5
Chain
chain:1-181
Reference Genes
BioGPS Gene:8490 RGS5
COSMIC (genes):RGS5 RGS5
CTD Gene:8490 RGS5
dbSNP Gene:8490 RGS5
ENSEMBL:ENSG00000143248 RGS5
HGNC:10001 RGS5
KEGG:hsa:8490 RGS5
Monarch:8490 RGS5
NCBI Gene:8490 RGS5
OMIM:603276 RGS5
UCSC:O15539 RGS5
Reference Transcript
RefSeq:NM_001254749.1 RGS5
RefSeq:NM_001195303.2 RGS5
RefSeq:NM_001254748.1 RGS5
RefSeq:NM_003617.3 RGS5
Other Identifiers
11722164_s_at
11722165_a_at
11722166_at
11757297_s_at
1555725_PM_a_at
1555725_a_at
16695791
209070_PM_s_at
209070_s_at
209071_PM_s_at
209071_s_at
218353_PM_at
218353_at
2441387
2441390
2441391
2441392
2441393
2441394
2441395
2441396
2441398
2441399
2441401
2441405
2441406
2441410
2441411
2441413
2441421
2441439
2441441
2441445
2441446
2441447
2441448
2441449
33890_at
57128_at
73927_at
7921916
8490
91092_at
A_23_P46045
A_23_P51518
A_33_P3243093
GE53227
GE83133
GO:0003824
GO:0003924
GO:0005096
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007186
GO:0008277
GO:0009968
GO:0016020
GO:0016787
GO:0043226
GO:0043231
GO:0098772
HMNXSV003028907
HMNXSV003057751
Hs.24950.0.S1_3p_a_at
Hs2.24950.3.S1_3p_s_at
ILMN_1651554
ILMN_2082273
PH_hs_0002190
TC01005900.hg
TC01006414.hg
g13376831_3p_at
g5230675_3p_a_at
p33352
p496
p505
Participates
as a member of
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
as a candidate of
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
Inferred To
RGS5 [plasma membrane]
(Bos taurus)
RGS5 [plasma membrane]
(Canis familiaris)
RGS5 [plasma membrane]
(Dictyostelium discoideum)
RGS5 [plasma membrane]
(Gallus gallus)
RGS5 [plasma membrane]
(Sus scrofa)
SST2 [plasma membrane]
(Saccharomyces cerevisiae)
Rgs5 [plasma membrane]
(Mus musculus)
Rgs5 [plasma membrane]
(Rattus norvegicus)
rgs-7 [plasma membrane]
(Caenorhabditis elegans)
rgs5a [plasma membrane]
(Danio rerio)
rgs1 [plasma membrane]
(Schizosaccharomyces pombe)
rgs5 [plasma membrane]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2812
ENSEMBL
ENSP00000432313
,
ENST00000530507
,
ENSP00000480891
,
ENST00000527988
,
ENSP00000433001
,
ENST00000618415
,
ENSP00000319308
,
ENSG00000143248
,
ENST00000313961
OpenTargets
ENSG00000143248
GeneCards
RGS5
HPA
ENSG00000143248-RGS5
PRO
O15539
Pharos - Targets
O15539
PDB
2CRP
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