Reactome | CORT(89-105) [extracellular region]

CORT(89-105) [extracellular region]

Stable Identifier

R-HSA-8849392

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Cortistatin-17, CORT_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        CORT(89-105) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00230 CORT

Gene Names

CORT, UNQ307/PRO350

Chain

signal peptide:1-18, propeptide:19-74, peptide:77-105, peptide:89-105

Reference Genes

BioGPS Gene:1325 CORT

COSMIC (genes):CORT CORT

CTD Gene:1325 CORT

dbSNP Gene:1325 CORT

ENSEMBL:ENSG00000241563.4 CORT

HGNC:2257 CORT

KEGG Gene (Homo sapiens):1325 CORT

Monarch:1325 CORT

NCBI Gene:1325 CORT

OMIM:602784 CORT

UCSC:O00230 CORT

Reference Transcript

RefSeq:NM_001302.4 CORT

Other Identifiers

0005860377

11732668_a_at

11732669_x_at

1325

210182_PM_at

210182_at

2319853

2319854

2319855

2319856

2319858

2319859

2319860

2319861

2319862

2319863

2319864

36016_at

A_23_P258164

A_24_P246926

GE54121

GO:0000712

GO:0001664

GO:0003682

GO:0005179

GO:0005184

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0006260

GO:0006310

GO:0007059

GO:0007193

GO:0007268

GO:0022414

GO:0023052

GO:0031297

GO:0032991

GO:0043226

GO:0043240

GO:0045202

GO:0071821

GO:0098772

GO:0140013

HMNXSV003042679

ILMN_1685575

ILMN_2071186

PH_hs_0024898

g2055231_3p_at

g2055231_3p_x_at

Participates

as a member of

Somatostatin, cortistatin [extracellular region] (Homo sapiens)

Inferred To

CORT [extracellular region] (Bos taurus)

CORT [extracellular region] (Sus scrofa)

SS2 [extracellular region] (Gallus gallus)

zgc:153708 [extracellular region] (Danio rerio)

Cort [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_001293.3

OpenTargets

ENSG00000241563

GeneCards

O00230

HPA

ENSG00000241563-CORT

Ensembl

ENSP00000366248, ENSG00000241563, ENST00000377049

PRO

O00230

Pharos - Targets

O00230

PDB

7VV4, 7VDL

HMDB Protein

HMDBP02623

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