Reactome | Dynein drives COPI-independent retrograde traffic from the Golgi to the ER

Dynein drives COPI-independent retrograde traffic from the Golgi to the ER

Stable Identifier

R-HSA-8849353

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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Dynein drives COPI-independent retrograde traffic from the Golgi to the ER

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The RAB6 pathway moves select retrograde cargo from the Golgi to the ER in a motor-dependent manner, although the precise details of this translocation remain to be worked out (Girod et al, 1999; White et al, 1999; reviewed in Heffernan and Simpson, 2014). Active RAB18 at the ER membrane may contribute to targeting and fusion of COPI-independent retrograde carriers through interaction with ER-localized tethering factors (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014)

Literature References

PubMed ID	Title	Journal	Year
24891604	Rab18 and a Rab18 GEF complex are required for normal ER structure Gerondopoulos, A, Bastos, RN, Yoshimura, S, Anderson, R, Carpanini, S, Aligianis, I, Handley, MT, Barr, FA	J. Cell Biol.	2014
18664496	Rab18 and Rab43 have key roles in ER-Golgi trafficking Dejgaard, SY, Murshid, A, Erman, A, Kizilay, O, Verbich, D, Lodge, R, Dejgaard, K, Ly-Hartig, TB, Pepperkok, R, Simpson, JC, Presley, JF	J. Cell. Sci.	2008
10562278	Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells White, J, Johannes, L, Mallard, F, Girod, A, Grill, S, Reinsch, S, Keller, P, Tzschaschel, B, Echard, A, Goud, B, Stelzer, EH	J. Cell Biol.	1999
25453831	Toward a comprehensive map of the effectors of rab GTPases Gillingham, AK, Sinka, R, Torres, IL, Lilley, KS, Munro, S	Dev. Cell	2014
25233431	The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport Heffernan, LF, Simpson, JC	Biochem. Soc. Trans.	2014
10559986	Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum Girod, A, Storrie, B, Simpson, JC, Johannes, L, Goud, B, Roberts, LM, Lord, JM, Nilsson, T, Pepperkok, R	Nat. Cell Biol.	1999