Reactome | RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo

RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo

Stable Identifier

R-HSA-8849348

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo

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COPI-independent retrograde traffic from the Golgi to the ER depends on RAB6 and involves formation of membrane tubules instead of classical transport vesicles. COPI-dependent and COPI-independent retrograde transport appear to have distinct cargo, as anti-COPI antibodies inhibit the traffic of KDEL-containing receptors, but not that of Shiga or Shiga-like toxins, or of Golgi-resident glycosylation enzymes (White et al, 1999; Girod et al, 1999). It is not yet clear how membrane tubules formation is initiated, however cargo type and concentration, as well as lipid composition may contribute (Martinez et al, 1997; Simpson et al, 2006; de Figueiredo et al, 1998; de Figueiredo et al, 1999; reviewed in Heffernan and Simpson 2014). The presence of sn2-lysophospholipids in the Golgi membrane generates curved membranes that are thought to favour tubule formation. Lysophospholipids are generated by the activity of phopholipase A2 enzymes that hydrolyze the fatty acid at the sn-2 position; this activity is counteracted by the activity of lysophospholipid acyltransferases (LPATs). The balance of these two activities at the Golgi membrane is thought to play a role in determining whether COPI-dependent or -independent transport is favoured (de Figueiredo et al, 1998; de Figueiredo et al, 1999; Schmidt et al, 2009; reviewed in Heffernan and Simpson, 2014). Recent studies have also implicated the coiled coil homodimer Bicaudal-D (BICD) proteins in COPI-independent retrograde traffic. BICD proteins bind RAB6:GTP with their C-terminal ends and the dynein:dynactin motor complex with their N-terminal ends and in this way are thought to facilitate the recruitment of motor proteins to the RAB6 retrograde pathway (Hoogenraad et al, 2001; Matanis et al, 2002; Young et al, 2005; Januschke et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
15483056	Regulation of microtubule-dependent recycling at the trans-Golgi network by Rab6A and Rab6A' Young, J, Stauber, T, del Nery, E, Vernos, I, Pepperkok, R, Nilsson, T	Mol. Biol. Cell	2005
10562278	Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells White, J, Johannes, L, Mallard, F, Girod, A, Grill, S, Reinsch, S, Keller, P, Tzschaschel, B, Echard, A, Goud, B, Stelzer, EH	J. Cell Biol.	1999
12447383	Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex Matanis, T, Akhmanova, A, Wulf, P, del Nery, E, Weide, T, Stepanova, T, Galjart, N, Grosveld, F, Goud, B, De Zeeuw, CI, Barnekow, A, Hoogenraad, CC	Nat. Cell Biol.	2002
11483508	Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes Hoogenraad, CC, Akhmanova, A, Howell, SA, Dortland, BR, De Zeeuw, CI, Willemsen, R, Visser, P, Grosveld, F, Galjart, N	EMBO J.	2001
9671731	Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation de Figueiredo, P, Drecktrah, D, Katzenellenbogen, JA, Strang, M, Brown, WJ	Proc. Natl. Acad. Sci. U.S.A.	1998
10359595	Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists de Figueiredo, P, Polizotto, RS, Drecktrah, D, Brown, WJ	Mol. Biol. Cell	1999
16314391	Biogenesis of tubular ER-to-Golgi transport intermediates Simpson, JC, Nilsson, T, Pepperkok, R	Mol. Biol. Cell	2006
9050864	GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum Martinez, O, Antony, C, Pehau-Arnaudet, G, Berger, EG, Salamero, J, Goud, B	Proc. Natl. Acad. Sci. U.S.A.	1997
17827179	Rab6 and the secretory pathway affect oocyte polarity in Drosophila Januschke, J, Nicolas, E, Compagnon, J, Formstecher, E, Goud, B, Guichet, A	Development	2007
25233431	The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport Heffernan, LF, Simpson, JC	Biochem. Soc. Trans.	2014
19635840	Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function Schmidt, JA, Brown, WJ	J. Cell Biol.	2009
10559986	Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum Girod, A, Storrie, B, Simpson, JC, Johannes, L, Goud, B, Roberts, LM, Lord, JM, Nilsson, T, Pepperkok, R	Nat. Cell Biol.	1999