AGPAT3 is an acyltransferase that can act on lysophosphatidylcholine to generate phosphatidylcholine (Prasad et al, 2011; Echard at al, 1998). This activity may counter the membrane tubule-inducing activity of Golgi PLA2 enzymes, thus favouring COPI-dependent vesicle formation over COPI-indendent retrograde traffic. While many lysophospholipid acyltransferases are ER-localized, AGPAT3 has been shown to also be present at the Golgi membrane, making it well situated to counter PLA2 activity during membrane tubule formation (Drecktah et al, 2003; Schmidt et al, 2009; reviewed in Ha et al, 2012; Heffernan and Simpson, 2014).
Prasad, SS, Agarwal, AK, Garg, A
Clarke, BA, Ha, KD, Brown, WJ
Drecktrah, D, Cluett, EB, Chambers, K, Gucwa, A, Jackson, B, Racoosin, EL, Brown, WJ
Simpson, JC, Heffernan, LF
Brown, WJ, Schmidt, JA
1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT3 [Golgi membrane]
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