Reactome | LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine

LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine

Stable Identifier

R-HSA-8849345

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine

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AGPAT3 is an acyltransferase that can act on lysophosphatidylcholine to generate phosphatidylcholine (Prasad et al, 2011; Echard at al, 1998). This activity may counter the membrane tubule-inducing activity of Golgi PLA2 enzymes, thus favouring COPI-dependent vesicle formation over COPI-indendent retrograde traffic. While many lysophospholipid acyltransferases are ER-localized, AGPAT3 has been shown to also be present at the Golgi membrane, making it well situated to counter PLA2 activity during membrane tubule formation (Drecktah et al, 2003; Schmidt et al, 2009; reviewed in Ha et al, 2012; Heffernan and Simpson, 2014).

Literature References

PubMed ID	Title	Journal	Year
21173190	Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria Prasad, SS, Agarwal, AK, Garg, A	J Lipid Res	2011
22562055	Regulation of the Golgi complex by phospholipid remodeling enzymes Clarke, BA, Ha, KD, Brown, WJ	Biochim. Biophys. Acta	2012
12925777	Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking Drecktrah, D, Cluett, EB, Chambers, K, Gucwa, A, Jackson, B, Racoosin, EL, Brown, WJ	Mol. Biol. Cell	2003
25233431	The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport Simpson, JC, Heffernan, LF	Biochem. Soc. Trans.	2014
19635840	Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function Brown, WJ, Schmidt, JA	J. Cell Biol.	2009