ARHGAP35 binds RHOA:GTP

Stable Identifier
R-HSA-8849085
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ARHGAP35 (p190 Rho GTPase activating protein) binds GTP-bound RHOA (Li et al. 1997). Phosphorylation of ARHGAP35 by SRC family kinases (Holinstat et al. 2006), including PTK6 (Shen et al. 2008), is necessary for ARHGAP35-mediated activation of Rho GTPase activity. It is uncertain whether phosphorylation of ARHGAP35 by SRC family kinases is necessary for binding to RHOA.

Literature References
PubMed ID Title Journal Year
9407060 Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190

Li, R, Zhang, B, Zheng, Y

J. Biol. Chem. 1997
16308318 Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability

Holinstat, M, Knezevic, N, Broman, M, Samarel, AM, Malik, AB, Mehta, D

J. Biol. Chem. 2006
18829532 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

Shen, CH, Chen, HY, Lin, MS, Li, FY, Chang, CC, Kuo, ML, Settleman, J, Chen, RH

Cancer Res. 2008
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