Reactome | ARHGAP35 binds RHOA:GTP

ARHGAP35 binds RHOA:GTP

Stable Identifier

R-HSA-8849085

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ARHGAP35 (p190 Rho GTPase activating protein) binds GTP-bound RHOA (Li et al. 1997). Phosphorylation of ARHGAP35 by SRC family kinases (Holinstat et al. 2006), including PTK6 (Shen et al. 2008), is necessary for ARHGAP35-mediated activation of Rho GTPase activity. It is uncertain whether phosphorylation of ARHGAP35 by SRC family kinases is necessary for binding to RHOA.

Literature References

PubMed ID	Title	Journal	Year
16308318	Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability Samarel, AM, Broman, M, Holinstat, M, Mehta, D, Malik, AB, Knezevic, N	J. Biol. Chem.	2006
9407060	Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190 Zhang, B, Zheng, Y, Li, R	J. Biol. Chem.	1997
18829532	Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion Kuo, ML, Li, FY, Settleman, J, Shen, CH, Chen, HY, Chang, CC, Chen, RH, Lin, MS	Cancer Res.	2008