CBL autoubiquitinates

Stable Identifier
R-HSA-8848829
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CBL autoubiquitinates
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PTK6-mediated phosphorylation promotes CBL autoubiquitination, targeting CBL for proteasome mediated degradation (Kang and Lee 2013).
Literature References
PubMed ID Title Journal Year
23352614 PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

Kang, SA, Lee, ST

Biochem. Biophys. Res. Commun. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of p-Y700,Y731,Y774-CBL [cytosol]

Physical Entity
p-Y700,Y731,Y774-CBL [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
CBL autoubiquitinates (Bos taurus)
CBL autoubiquitinates (Caenorhabditis elegans)
CBL autoubiquitinates (Canis familiaris)
CBL autoubiquitinates (Danio rerio)
CBL autoubiquitinates (Drosophila melanogaster)
CBL autoubiquitinates (Gallus gallus)
CBL autoubiquitinates (Mus musculus)
CBL autoubiquitinates (Plasmodium falciparum)
CBL autoubiquitinates (Rattus norvegicus)
CBL autoubiquitinates (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)
Cite Us!