CBL autoubiquitinates

Stable Identifier
R-HSA-8848829
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CBL autoubiquitinates
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PTK6-mediated phosphorylation promotes CBL autoubiquitination, targeting CBL for proteasome mediated degradation (Kang and Lee 2013).
Literature References
PubMed ID Title Journal Year
23352614 PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

Lee, ST, Kang, SA

Biochem. Biophys. Res. Commun. 2013
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of p-Y700,Y731,Y774-CBL [cytosol]

Physical Entity
p-Y700,Y731,Y774-CBL [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
CBL autoubiquitinates (Bos taurus)
CBL autoubiquitinates (Caenorhabditis elegans)
CBL autoubiquitinates (Canis familiaris)
CBL autoubiquitinates (Danio rerio)
CBL autoubiquitinates (Drosophila melanogaster)
CBL autoubiquitinates (Gallus gallus)
CBL autoubiquitinates (Mus musculus)
CBL autoubiquitinates (Plasmodium falciparum)
CBL autoubiquitinates (Rattus norvegicus)
CBL autoubiquitinates (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)
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