PTK6 phosphorylates CBL

Stable Identifier
R-HSA-8848818
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PTK6 (BRK) phosphorylates CBL at tyrosine residues Y700, Y731 and Y774, which are also targeted by other SRC family kinases. It has not been examined whether CBL and PTK6 interact directly. However, it has been shown that CBL expression is reciprocal (inversely related) to PTK6 in several cancer cell lines (Pires et al. 2014). CBL is an E3 ubiquitin ligase that negatively regulates EGFR, targeting it for degradation (Kang and Lee 2013). CBL is also implicated as a putative E3 ubiquitin ligase for PTK6 in normoxia (Pires et al. 2014).

Literature References
PubMed ID Title Journal Year
25019382 HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

Span, PN, Pires, IM, Hammond, EM, Eccles, SA, Blokland, NJ, Poujade, FA, Senra, JM, Broos, AW, Harvey, AJ

Cancer Biol. Ther. 2014
23352614 PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

Lee, ST, Kang, SA

Biochem. Biophys. Res. Commun. 2013
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6 [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!