HIF1A,EPAS1 bind PTK6 gene

Stable Identifier
R-HSA-8848812
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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HIF1A (HIF1-alpha) and/or EPAS1 (HIF2A), probably in association with other transcription factors, binds hypoxia response elements (HREs) in the promoter region of the PTK6 (BRK) gene (Regan Anderson et al. 2013). EPAS1 was recently found to cooperate with the activated glucocorticoid receptor NR3C1 (GCR) and its cofactor PELP1 in binding to the adjacent hypoxia response and glucocorticoid response PTK6 promoter elements (Regan Anderson et al. 2016).

Literature References
PubMed ID Title Journal Year
26825173 Breast Tumor Kinase (Brk/PTK6) is Induced by HIF, Glucocorticoid Receptor and PELP1 Mediated Stress Signaling in Triple-Negative Breast Cancer

Regan Anderson, TM, Ma, SH, Raj, GV, Cidlowski, JA, Helle, TM, Knutson, TP, Krutilina, R, Seagroves, TN, Lange, CA

Cancer Res. 2016
23928995 Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression

Regan Anderson, TM, Peacock, DL, Daniel, AR, Hubbard, GK, Lofgren, KA, Girard, BJ, Schörg, A, Hoogewijs, D, Wenger, RH, Seagroves, TN, Lange, CA

Cancer Res. 2013
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